PMID: 8947943Nov 1, 1996Paper

Domoic acid: neurobehavioral and neurohistological effects of low-dose exposure in adult rats

Neurotoxicology and Teratology
T SobotkaA C Scallet

Abstract

Adult rats treated IP with domoic acid at 0, 0.22, 0.65, or 1.32 mg/kg were tested for passive avoidance (PA), auditory startle (AS), or conditioned avoidance (CAR) behaviors. Clinical signs were observed only at the 1.32 mg/kg dose level. Within 24 h of dosing, rats surviving a dose of 1.32 mg/kg exhibited transient decreased body weight and exaggerated AS responding. Startle latency and habituation, PA, and CAR were not affected. Examination of brains from six rats per group revealed a subset (2/6) of animals receiving 1.32 mg/kg domoic acid with degenerating neurons in the hippocampal CA1/CA3 subregions and gliosis. The decreased body weight and increased startle suggest a hyperreactivity syndrome possibly related to neuronal degeneration in the hippocampus. In a separate experiment, domoic acid at an IP dose of 0.93 mg/kg was found to produce hypomotility in addition to a decrease in body weight. Both effects were reduced by pretreatment with scopolamine (2 mg/kg), but not with caffeine (30 mg/kg), indicating a possible cholinergic involvement in domoate's toxicity.

References

Dec 1, 1992·Canadian Journal of Psychology·S Nakajima, J L Potvin
Jun 1, 1992·Neuroreport·D G MacGregor, T W Stone
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·B F PetrieG B Glavin
May 11, 1992·Annals of the New York Academy of Sciences·H RobertsonT White
Jan 1, 1991·Neuroscience·S M Strain, R A Tasker
Jun 21, 1990·The New England Journal of Medicine·T M PerlR S Remis
Jun 21, 1990·The New England Journal of Medicine·J S TeitelbaumN R Cashman
Oct 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L TryphonasF Iverson
Dec 1, 1989·Pharmacology, Biochemistry, and Behavior·G E HandelmannA A Cordi
Jun 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F IversonE Lok
Nov 1, 1987·Neurotoxicology and Teratology·H A Tilson
Nov 1, 1994·Pharmacology, Biochemistry, and Behavior·J E FinkelsteinH L Petri
Jan 1, 1994·Natural Toxins·F Iverson, J Truelove
Mar 1, 1994·Neurochemistry International·M AlfonsoA P Carvalho
Apr 1, 1994·Bulletin of Environmental Contamination and Toxicology·J Truelove, F Iverson
Nov 1, 1993·Epilepsia·G R SutherlandC Pinsky

❮ Previous
Next ❯

Citations

Aug 25, 2004·Neurotoxicity Research·Ananth ChandrasekaranCharanjit Kaur
Mar 17, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B JefferyC Boyle
Mar 17, 2004·Neurotoxicology and Teratology·Andrew C ScalletZbigniew K Binienda
Sep 15, 1999·Toxicon : Official Journal of the International Society on Toxinology·E C ClaytonJ S Ramsdell
Jun 5, 2003·Neurotoxicology·G Jean Harry, Christian Lefebvre d'Hellencourt
Jun 6, 2000·Journal of Neuroscience Methods·A C ScalletJ C Matthews
Nov 25, 1997·Annals of the New York Academy of Sciences·A C Scallet, X Ye
Aug 30, 2008·Marine Drugs·Olga M Pulido
Dec 1, 2010·Marine Drugs·Isabel NogueiraVítor Vasconcelos
Oct 22, 2010·Environmental Toxicology and Chemistry·Karen H WatanabeIrvin R Schultz
Mar 16, 2016·Toxins·Andres C VieiraLuis M Botana
May 1, 2005·Environmental Toxicology and Pharmacology·L G CostaA Vitalone
Oct 6, 2005·Neurotoxicology and Teratology·Andrew C ScalletJan N Johannessen
Apr 7, 2016·Behavioural Brain Research·Brian D MillsGaret P Lahvis
Jun 28, 2011·The American Journal of Pathology·Alexandra Vranyac-TramoundanasIvan A Sammut
Oct 6, 2009·Neurotoxicology and Teratology·Kimberly S GrantLynn Gratttan
Oct 18, 2016·Harmful Algae·Lynn M GrattanJ Glenn Morris
Oct 14, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anabel Pérez-GómezAntonello Novelli
May 1, 2021·Pharmacology & Therapeutics·Rebekah PetroffThomas M Burbacher

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.