Domperidone, an extracerebral inhibitor of dopamine receptors, stimulates thyrotropin and prolactin release in man

The Journal of Clinical Endocrinology and Metabolism
G DelitalaG Lotti

Abstract

Domperidone, an extracerebral dopamine receptor antagonist, was given im to 12 normal subjects and to a group of patients with subclinical hypothyroidism to study its effect on PRL and TSH secretion. Domperidone induced in all subjects a quick and marked increment of serum PRL. At 180 min, the levels remained high. A small but significant increase of TSH was also observed in normal as well as in hypothyroid subjects. Since domperidone does not cross the blood-brain barrier, the hormonal changes observed may be mediated through the pituitary and median eminence, tissues which lie outside of the blood-brain barrier.

Citations

Mar 1, 1987·European Journal of Pediatrics·A R DeprettereM V Du Caju
Nov 1, 1988·Medical Toxicology and Adverse Drug Experience·K Hell, H Wernze
Mar 22, 2016·Animal Science Journal = Nihon Chikusan Gakkaihō·Yuki InabaTsutomu Hashizume
Jul 1, 1981·Metabolism: Clinical and Experimental·K W Wenzel
Jan 1, 1988·Neuroscience and Biobehavioral Reviews·K DakshinamurtiY L Siow
Dec 1, 1983·Gastroenterologia Japonica·A FunakoshiH Ibayashi
May 31, 2017·Animal Science Journal = Nihon Chikusan Gakkaihō·Tsutomu HashizumeGyörgy Miklos Nagy
Dec 1, 1983·Asia-Oceania Journal of Obstetrics and Gynaecology·H KatoT Torigoe

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