Domperidone for increasing breast milk volume in mothers expressing breast milk for their preterm infants: a systematic review and meta-analysis

BJOG : an International Journal of Obstetrics and Gynaecology
L E GrzeskowiakR M Grivell

Abstract

Mothers of preterm infants often struggle to produce enough breast milk to meet the nutritional needs of their infant. Galactagogues such as domperidone are often prescribed to increase breast milk supply but evidence supporting their role in clinical practice is uncertain. To evaluate the efficacy and safety of domperidone for increasing breast milk volume in mothers expressing breast milk for their preterm infants. MEDLINE, Embase and Web of Science were searched without language restrictions from first publication until January 2017. Bibliographies of articles and reviews were hand-searched for additional reports. Randomised controlled trials that compared domperidone with placebo in mothers of preterm infants (<37 weeks' gestation) experiencing insufficient milk supply. Two review authors independently assessed studies for inclusion, extracted data and evaluated study quality. Differences in breast milk volume and adverse events were combined using fixed effects meta-analysis. The pooled analysis of five trials consisting of 194 women demonstrated a moderate increase in daily breast milk volume of 88.3 ml/day (95% CI 56.8-119.8) with the use of domperidone compared with placebo. No difference was evident with respect to mat...Continue Reading

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Citations

Jun 15, 2018·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Wendy Brodribb
May 5, 2018·European Journal of Clinical Pharmacology·Luke E GrzeskowiakLisa G Smithers
Nov 18, 2020·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Meera KhoranaWiboon Kanjanapattanakul
Dec 5, 2020·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Zainab AbdulHadi Al-Mohsen, Hasan Frookh Jamal
Nov 13, 2020·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Lara A Tauritz BakkerPatricia M L A van den Bemt
Mar 27, 2021·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Quan ShenYan-Qiong Ouyang

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