Domperidone-induced potentiation of ventilatory responses in awake goats

Respiration Physiology
N A KressinG E Bisgard

Abstract

Dopamine has been implicated in maintaining tonic inhibition of carotid body activity. We tested this hypothesis by assessing the ventilatory effects of a peripheral dopamine antagonist, domperidone. The effects of this agent on the ventilatory responses to hypoxia and hypercapnia were also examined. The study was performed in awake carotid body intact and carotid body denervated goats. Resting minute ventilation increased while PaCO2 decreased (4 Torr) following domperidone administration (0.5 mg/kg, I.V.) in carotid body intact goats. This response did not occur in carotid body denervated goats supporting the hypothesis that endogenous dopamine provides tonic inhibition in the carotid body. Hypoxic and hypercapnic ventilatory responses were significantly augmented following domperidone administration in the carotid body intact goats. This supports the concept of dopaminergic modulation of the response of the carotid body to stimuli. Domperidone allows study of carotid chemoreceptor dopaminergic activity in awake animals because of its high affinity for carotid body D2 dopamine receptors and its lack of CNS effects.

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Citations

Mar 1, 1988·Pflügers Archiv : European journal of physiology·A BerkenboschJ DeGoede
Jun 1, 1989·Respiration Physiology·C HsiaoA Mokashi
Sep 1, 1990·Respiration Physiology·S Javaheri, L F Guerra
Dec 1, 1992·Respiration Physiology·J PizarroG E Bisgard
Dec 15, 1989·Neuroscience Letters·M J EngwallG E Bisgard
Mar 13, 1998·Respiration Physiology·P L JanssenG E Bisgard
Jun 18, 2003·Respiratory Physiology & Neurobiology·K A HueyF L Powell
Jun 18, 2003·Respiratory Physiology & Neurobiology·Jay K HermanGerald E Bisgard
Dec 12, 2002·Chest·Tarja Saaresranta, Olli Polo
May 20, 2009·Respiratory Physiology & Neurobiology·John T Fisher
Aug 1, 1987·Respiration Physiology·G E BisgardH V Forster
Oct 1, 2008·Respiratory Physiology & Neurobiology·Bradley A EdwardsPhilip J Berger
Aug 1, 1995·Pediatric Pulmonology·L CattarossiW A Carlo
May 17, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Sonia Velez-RoaPhilippe van de Borne
Dec 18, 2001·Journal of Applied Physiology·Hitoshi NakanoGaspar A Farkas
Sep 8, 1998·Journal of Applied Physiology·K D O'HalloranG E Bisgard

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