PMID: 3745846Apr 1, 1986Paper

Domperidone, metoclopramide, and placebo. All give symptomatic improvement in gastroesophageal reflux

Journal of Clinical Gastroenterology
G J MaddernG G Jamieson

Abstract

A double-blind crossover study was conducted of two gastric prokinetic drugs in 23 patients with gastroesophageal reflux. Patients were divided into two groups on the basis of a dual-isotope mixed-meal study of their gastric emptying (GE). Group I had normal GE and group II delayed GE. Nine gastrointestinal symptoms were assessed for frequency and severity before treatment. The trial had three 1-month treatment periods using metoclopramide 10 mg q.i.d., domperidone 20 mg q.i.d., or placebo on a random basis. Symptoms were reassessed at the end of each month. Taken as a whole, the group showed a significant symptomatic response in all three treatment periods (p less than 0.0001), but patients with delayed or normal GE did not differ significantly in their symptomatic response. Eleven patients complained of side effects with metoclopramide and three stopped therapy before the 1-month course was completed. Two patients described side effects with domperidone, including one woman with galactorrhea after 36 h of treatment. Three patients on placebo also complained of important side effects. We conclude that a significant placebo effect is present in the treatment of gastroesophageal reflux. No significant difference was demonstrated...Continue Reading

Citations

Sep 4, 2013·Best Practice & Research. Clinical Gastroenterology·Usha Dutta, Paul Moayyedi
Nov 19, 2013·Current Opinion in Otolaryngology & Head and Neck Surgery·Edoardo SavarinoVincenzo Savarino
Oct 1, 1993·Journal of Internal Medicine·G Bianchi Porro, F Pace
Jul 1, 1995·Archives of Disease in Childhood·A E Davies, B K Sandhu
Sep 1, 1988·The Australian Nurses' Journal·S Wilson
Dec 1, 1988·Journal of Clinical Pharmacy and Therapeutics·M Deakin, J G Temple
May 10, 2007·The American Journal of Gastroenterology·Savio C ReddymasuRichard W McCallum
Jul 3, 2015·United European Gastroenterology Journal·Charlotte ScheerensNathalie Rommel
Sep 24, 2013·Surgical Innovation·Nancy Salloum HarrisonChristopher J Lahr
Feb 20, 2013·The American Journal of Gastroenterology·Philip O KatzMarcelo F Vela
Jul 23, 2011·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·R KeldS Lal
Nov 29, 2012·Journal of Cardiovascular Pharmacology·Luc M Hondeghem

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Drug Safety : an International Journal of Medical Toxicology and Drug Experience
Charlotte van NoordMiriam C J M Sturkenboom
Clinical Neuropharmacology
J D Parkes
Alimentary Pharmacology & Therapeutics
A S Rao, M Camilleri
© 2021 Meta ULC. All rights reserved