Donkey and goat milk intake and modulation of the human aged immune response

Current Pharmaceutical Design
L AmatiE Jirillo

Abstract

In a group of 14 healthy aged subjects, donkey and goat milk was administered respectively, for a period of one month. Cytokine profile [interleukin (IL)-12, IL-10, IL-1beta, IL-8, IL-6 and Tumor Necrosis Factor (TNF)-alpha] was assessed before and after milk intake by means of a cytometric bead array test. Data demonstrated that IL-12 was undetectable, while IL-10, IL-1beta and TNF-alpha were released in very low amounts. Quite interestingly, IL-8 was increased by donkey milk administration, while same cytokine was dramatically decreased following goat milk intake. Same pattern of response was noted with IL-6 even if levels of these cytokine were lower than those detectable in the case of IL-8. Taken together, these findings indicate that administration of donkey milk in the aged host is able to upregulate the immune response, while goat milk seems to reduce the exaggerated acute phase response in elderly.

Citations

Sep 12, 2012·Lipids in Health and Disease·Giovanni Martemucci, Angela Gabriella D'Alessandro
Oct 17, 2014·Equine Veterinary Journal·M AliA Nadeem
Dec 2, 2014·The Journal of Dairy Research·Angela Gabriella D'AlessandroGiovanni Martemucci
Sep 30, 2019·Journal of Dairy Science·A G D'AlessandroM Faccia
Jul 30, 2020·Animals : an Open Access Journal From MDPI·Michele FacciaYonas Hailu
Mar 25, 2011·Immunopharmacology and Immunotoxicology·Biagina ChiofaloLuigi Mondello
Oct 24, 2017·Veterinary Sciences·Marzia GiribaldiLaura Cavallarin
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Mina MartiniFederica Salari
Aug 12, 2021·The Journal of Dairy Research·Angela Gabriella D'AlessandroMichele Faccia

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