Donor ABCB1 3435 C>T genetic polymorphisms influence early renal function in kidney transplant recipients treated with tacrolimus

Pharmacogenomics
Lin YanYunying Shi

Abstract

Determine the effect of genetic variants of donors and recipients on early renal function and tacrolimus pharmacokinetics in kidney transplant recipients. We measured CYP3A5 (6986A>G), ABCB1 (3435C>T, 2677G>T/A, 1236C>T) genetic polymorphisms in 120 renal transplant recipients and donors by high-resolution melting curve analysis. The renal function and tacrolimus trough concentrations were analyzed. The genotype of CYP3A5 (6986A>G) in recipients showed strong influence on tacrolimus pharmacokinetics. The ABCB1 3435 CC genotype in donor was significantly associated with lower estimated glomerular filtration in recipients within 1 month (p < 0.05) and correlated with delayed creatinine recovery (p = 0.007). ABCB1 3435 CC genotype in donor influences early renal function and creatinine recovery in tacrolimus-treated kidney transplant recipients.

References

Dec 23, 2006·Science·Chava Kimchi-SarfatyMichael M Gottesman
Sep 19, 2009·Journal of the American Society of Nephrology : JASN·Maarten NaesensDirk R J Kuypers
Mar 26, 2011·Expert Opinion on Drug Metabolism & Toxicology·Nicolas Picard, Pierre Marquet
Jun 17, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·François GlowackiChristelle Cauffiez
Oct 16, 2012·Journal of the American Society of Nephrology : JASN·Jason MooreRichard Borrows
Sep 26, 2013·Therapeutic Drug Monitoring·Laure ElensRon H N van Schaik
Feb 18, 2014·British Journal of Clinical Pharmacology·Diego Alberto C CusinatoEduardo B Coelho
Aug 28, 2014·Current Opinion in Nephrology and Hypertension·Kelly Birdwell

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