Donor age and mechanosensitivity of human bone cells

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
J Klein-NulendE H Burger

Abstract

With increasing age the human skeleton decreases in density, thereby compromising its load-bearing capacity. Mechanical loading activates bone formation, but an age-dependent decrease in skeletal mechanoresponsiveness has been described in rats. In this paper we examine whether age-related bone loss is reflected by a decrease in the mechanosensitivity of isolated bone cells from human donors. Bone cell cultures were obtained from 39 donors (males and females) between 7 and 85 years of age. Cultures were challenged with 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) or mechanically stressed by treatment with pulsating fluid flow (PFF; 0.7 +/- 0.03 Pa at 5 Hz for 1 h). The growth capacity of the bone-derived cell population almost halved between 7 and 85 years of age. Basal alkaline phosphatase activity of the cells increased with donor age, while the response to 1,25(OH)2D3, measured as stimulated osteocalcin production, decreased with age. Together this suggests that the cell cultures from older donors represented a more mature, slower-growing cell population than the cultures from young donors. All cell cultures responded to mechanical stress with enhanced release of prostaglandin E2 (PGE2) and I2 (PGI2). The magnitude of the response...Continue Reading

Citations

Sep 17, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Peter AugatLutz Claes
May 30, 2008·Calcified Tissue International·Matthew J Silva, Michael D Brodt
Jul 23, 2005·Current Osteoporosis Reports·Jenneke Klein-NulendElisabeth H Burger
Dec 28, 1999·Journal of Biomechanics·M JoldersmaJ Klein-Nulend
May 26, 1998·Bone·E H Burger, J Klein-Nulend
Aug 25, 2005·British Journal of Sports Medicine·G Vicente-RodriguezJ A L Calbet
Sep 15, 2010·PLoS Computational Biology·Sundar SrinivasanTed S Gross
Feb 18, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A IrelandJ Rittweger
Jul 17, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J L PathakA D Bakker
Feb 19, 2016·Calcified Tissue International·Janak L PathakNathalie Bravenboer
Jan 14, 2012·Ageing Research Reviews·Sundar SrinivasanSteven D Bain
Jul 30, 2015·Biomechanics and Modeling in Mechanobiology·Stefan ScheinerChristian Hellmich
Dec 15, 2015·Progress in Biophysics and Molecular Biology·Yu YuanJun Zou
Jul 3, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Fernando RivadeneiraAndre' G Uitterlinden
Jul 12, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Teppo L N JärvinenPekka Kannus
Apr 27, 2012·Journal of Cellular Biochemistry·Angela E OostlanderUNKNOWN Dutch Initiative on Crohn and Colitis (ICC)
Jun 19, 2013·International Journal for Numerical Methods in Biomedical Engineering·Gaël Y Rochefort, Claude-Laurent Benhamou
May 26, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael D Brodt, Matthew J Silva
Dec 21, 2005·Pathologie-biologie·J Klein-NulendM G Mullender
Sep 27, 2005·Micron : the International Research and Review Journal for Microscopy·Franchi MarcoOttani Vittoria
Apr 11, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hajar RaziSara Checa
Mar 13, 2013·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Celeste J HamiltonUNKNOWN Canadian Multicentre Osteoporosis Study (CaMos) Research Group
May 26, 2015·Biochimica Et Biophysica Acta·Anastasia SpyropoulouEfthimia K Basdra
May 15, 2015·Calcified Tissue International·Janak L PathakAstrid D Bakker
Jan 15, 2015·Journal of Biomechanics·Jenneke Klein-NulendRommel G Bacabac
Jun 4, 2014·Therapeutic Advances in Musculoskeletal Disease·Gaël Y Rochefort
Feb 25, 2018·Current Osteoporosis Reports·Vihitaben S PatelClinton T Rubin
Dec 20, 2013·The Journal of Advanced Prosthodontics·Ran ParkHong-Seok Moon
May 18, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Margriet G MullenderJenneke Klein-Nulend
Nov 25, 2019·Current Osteoporosis Reports·Behzad Javaheri, Andrew A Pitsillides
Apr 3, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sudha AgarwalRobert Gassner
Oct 28, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Angela P Bastidas-CoralTymour Forouzanfar
Jul 28, 2020·Calcified Tissue International·Valeria CarinaGianluca Giavaresi
Mar 1, 2019·Nature Reviews. Endocrinology·Gabriel M PagnottiClinton T Rubin
May 30, 2021·Bone·Scott Birks, Gunes Uzer

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