Abstract
The study objective is to quantify the impact of donor and recipient variables on heart transplant survival in recipients with a significant proportion of implanted continuous-flow left ventricular assist devices (LVADs). This is a prospective cohort study of International Society for Heart and Lung Transplantation (ISHLT) Registry that includes all primary heart-alone transplants in adult recipients (January 2005 and June 2013, N = 15 532, 27% LVADs). Donor and recipient characteristics were assessed for association with death or graft failure within 90 days and between 90 days and 5 years after transplantation. On Cox proportional hazard model donor cause of death other than head trauma (hazard ratio [HR] 1.985, P < 0.0001), recipient congenital (HR 2.7555, P < 0.0001) and ischemic (HR 1.165, P = 0.0383) vs dilated etiology and female donor heart transplanted into male recipient (HR 1.207, P = 0.0354) were predictors of death or graft failure within 90 days. Between 90 days and 5 years, donor cigarette use (HR 1.232, P = 0.0001), recipient cigarette use (HR 1.193, P = 0.0003), diabetes (HR 1.159, P = 0.0050), arterial hypertension (HR 1.129, P = 0.0115), and ischemic vs dilative cardiomyopathy had an increased probability of ...Continue Reading
References
Sep 1, 2004·The Annals of Thoracic Surgery·Dipin GuptaSatoshi Furukawa
Mar 28, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Abdulaziz Al-KhaldiRobert C Robbins
Jan 30, 2007·The Journal of Thoracic and Cardiovascular Surgery·Mark J RussoYoshifumi Naka
Oct 22, 2008·Transplantation Proceedings·C I TsaoS S Wang
Oct 7, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Josef StehlikUNKNOWN Cardiac Transplant Research Database Group
Oct 8, 2009·Circulation. Heart Failure·Eric S WeissJohn V Conte
Nov 19, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Eric S WeissAshish S Shah
Dec 20, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jacqueline M SmitsAndreas Zuckermann
Mar 31, 2012·Transplantation Reviews·Bernhard FloerchingerStefan G Tullius
Aug 7, 2013·The Annals of Thoracic Surgery·Simon MaltaisMary E Keebler
Nov 30, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Marcus KutschmannNils R Frühauf
Feb 14, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K K KhushB A Goldstein
Dec 1, 2015·Journal of Cardiac Failure·Olga LaurJeffrey M Testani
Dec 29, 2015·Transplantation Proceedings·R A SorabellaI George
Feb 15, 2016·JACC. Heart Failure·Lily E JohnstonAshish S Shah
Jul 20, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Barbara Stella DoumourasHeather Joan Ross
Mar 6, 2017·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Henrik BergenfeldtJohan Nilsson
May 16, 2017·Heart & Lung : the Journal of Critical Care·Anne JalowiecConnie White-Williams
Aug 7, 2017·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Lars H LundUNKNOWN International Society for Heart and Lung Transplantation
Aug 22, 2017·The American Surgeon·Eno-Obong EssienDeborah M Stein
Sep 1, 2017·Heart·Farid ForoutanHeather Ross
Mar 21, 2018·Texas Heart Institute Journal·Heidi J ReichFardad Esmailian
Citations
Mar 22, 2020·Pediatric Transplantation·Jeffrey G GossettRyan R Davies
Jul 25, 2019·Journal of Cardiothoracic Surgery·Eilon RamYael Peled
Oct 24, 2019·Kardiologiia·D V ShumakovD I Zybin