Donor biomarkers as predictors of organ use and recipient survival after neurologically deceased donor organ transplantation

Journal of Critical Care
Shengnan LiMonitoring Organ Donors to Improve Transplantation Results (MOnIToR) Study Investigators

Abstract

We sought to build prediction models for organ transplantation and recipient survival using both biomarkers and clinical information. We abstracted clinical variables from a previous randomized trial (n = 556) of donor management. In a subset of donors (n = 97), we measured two candidate biomarkers in plasma at enrollment and just prior to explantation. Secretory leukocyte protease inhibitor (SLPI) was significant for predicting liver transplantation (C-statistic 0.65 (0.53, 0.78)). SLPI also significantly improved the predictive performance of a clinical model for liver transplantation (integrated discrimination improvement (IDI): 0.090 (0.009, 0.210)). For other organs, clinical variables alone had strong predictive ability (C-statistic >0.80). Recipient 3-years survival was 80.0% (71.9%, 87.0%). Donor IL-6 was significantly associated with recipient 3-years survival (adjusted Hazard Ratio (95%CI): 1.26(1.08, 1.48), P = .004). Neither clinical variables nor biomarkers showed strong predictive ability for 3-year recipient survival. Plasma biomarkers in neurologically deceased donors were associated with organ use. SLPI enhanced prediction within a liver transplantation model, whereas IL-6 before transplantation was significant...Continue Reading

Associated Clinical Trials

References

May 3, 2002·Journal of the American College of Cardiology·Gabriele PlenzMario C Deng
Sep 1, 2004·The Annals of Thoracic Surgery·Dipin GuptaSatoshi Furukawa
Dec 15, 2005·The Journal of Experimental Medicine·Clifford C TaggartNoel G McElvaney
Feb 4, 2006·The Lancet Oncology·Dominique BouchardGuy M Tremblay
Feb 24, 2006·Journal of Cardiac Surgery·Veli K TopkaraYoshifumi Naka
May 9, 2006·The Journal of Thoracic and Cardiovascular Surgery·Phil BothaStephan V B Schueler
Feb 26, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S SchneebergerA Amberger
Feb 3, 2009·Journal of the American College of Surgeons·Christopher D AndersonWilliam C Chapman
May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luqiu ChenMaria-Luisa Alegre
May 20, 2009·Journal of Hepato-biliary-pancreatic Sciences·Minna IlmakunnasEero J Pesonen
Jun 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J A DiazD K Bishop
Dec 22, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Christian F BulcaoShahab A Akhter
Apr 22, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Scott C QuinlanEric A Engels
Apr 23, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Dag Olav DahleHallvard Holdaas
Apr 28, 2012·American Journal of Reproductive Immunology : AJRI·Morris D CooperGary A Jarvis
Oct 30, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T SaitoS Keshavjee
Nov 28, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Charalambos Gustav AntoniadesMark Thursz
Jan 1, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A K IsraniB L Kasiske
Sep 6, 2014·Cold Spring Harbor Perspectives in Biology·Toshio TanakaTadamitsu Kishimoto
Jan 15, 2015·Intensive Care Medicine·Ali Al-KhafajiJohn A Kellum
Jul 21, 2015·Cytokine & Growth Factor Reviews·Fred Schaper, Stefan Rose-John
Jan 1, 2016·Cytokine & Growth Factor Reviews·Monika Majchrzak-GoreckaJoanna Cichy
Jun 3, 2016·Interactive Cardiovascular and Thoracic Surgery·Themistokles ChamogeorgakisBrian Lima
Aug 9, 2016·Current Neurology and Neuroscience Reports·Carolina B Maciel, David M Greer
Feb 16, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J ChoiS C Jordan

❮ Previous
Next ❯

Citations

Mar 2, 2019·Intensive Care Medicine·Ignacio Martin-LoechesGlauco A Westphal
Oct 4, 2020·Journal of Biomedical Science·K WalweelJ F Fraser
Mar 25, 2021·Scientific Reports·Lorenzo PiemontiMassimo Cardillo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Francia Díaz Jaime, Marina Berenguer
© 2022 Meta ULC. All rights reserved