Donor bone marrow transplantation: chimerism and tolerance

Transplant Immunology
Spiros DelisJoshua Miller

Abstract

Infusion of donor bone marrow (DBM)-derived cells continue to be tested in clinical protocols intended to induce specific immunologic tolerance. Central clonal deletion of donor-specific alloreactive cells associated with mixed chimerism reliably produced long-term graft tolerance. In this setting, depletion of recipient T cells by antilymphocyte antibodies and subsequent repopulation by donor hematopoietic cells after donor bone marrow infusion (DBMI) are prerequisites for tolerance induction. Major advances have been made in animal models and in pilot clinical trials and the key questions with the future perspectives are presented in this article.

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Citations

Oct 10, 2013·World Journal of Gastroenterology : WJG·Sheng-Li Wu, Cheng-En Pan
Sep 9, 2015·Frontiers in Immunology·Yanxia Guo, Adele Y Wang
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Mar 15, 2019·Reviews on Recent Clinical Trials·Tommaso Maria ManziaGiuseppe Tisone

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