Donor lymphocyte infusions to displace residual host hematopoietic cells after allogeneic bone marrow transplantation for beta-thalassemia major

Journal of Pediatric Hematology/oncology
M AkerR Or

Abstract

Donor lymphocyte infusion (DLI) was used to reverse relapse after allogeneic bone marrow transplantation (BMT) in a patient with beta-thalassemia major. The patient with unstable mixed chimerism after BMT was treated with graded increments of donor lymphocytes (10(5) T cells/kg to 5 x 10(7) T cells/kg) to displace residual hematopoietic host cells. DLI resulted in complete donor-derived reconstitution of the hematopoietic compartment. The patient developed mild graft-versus-host disease (GVHD) that could be controlled by steroid treatment. This case report shows that DLI can effectively eradicate host stem cells in mixed chimeras after BMT in nonmalignant hematopoietic diseases.

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Citations

Nov 15, 2002·International Journal of Hematology·Surapol Issaragrisil
Sep 28, 2000·Current Opinion in Immunology·S Slavin
Apr 25, 2003·Critical Reviews in Oncology/hematology·Shimon SlavinReuven Or
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Jul 17, 2021·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Akanksha GargSonia Parikh

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