Donor lymphocyte transfusion for the treatment of Epstein-Barr virus-associated lymphoproliferative disorder of the brain

Bone Marrow Transplantation
K NagafujiY Niho

Abstract

EBV-associated lymphoproliferative disorder (LPD) is a rare but serious complication in marrow transplant recipients. A 31-year-old Japanese woman in the second chronic phase of CML received an allogeneic BMT from her HLA 2-locus-incompatible 62-year-old father. Around day +200, she developed EBV-LPD of the right parieto-temporal lobe which caused slowly progressive left hemiparesis. Two courses of donor lymphocyte transfusions (DLT) of 10(6)CD3+ T cells/kg of body weight failed to suppress her central nervous system (CNS) EBV-LPD. The patient died of recurrent blastic crisis of CML. This case suggests that DLT may be ineffective for the treatment of CNS EBV-LPD.

Citations

Feb 27, 2004·American Journal of Clinical Pathology·Amilcar A Castellano-SanchezDaniel J Brat
Dec 29, 2004·Leukemia & Lymphoma·Stephen GottschalkCliona M Rooney
Apr 1, 2004·Expert Opinion on Therapeutic Patents·Astrid MeerbachPeter Wutzler

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