Donor or recipient hepatitis B seropositivity is associated with allograft vasculopathy

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Showkat A HajiRandall C Starling

Abstract

Increasing interest has focused on possible viral triggers of cardiac allograft vasculopathy. Although much interest has centered on cytomegalovirus, it has recently been noted that donor hepatitis C seropositivity is associated with risk for accelerated vasculopathy. The current study hypothesized that hepatitis B (HBV) might be associated with accelerated vasculopathy. Sixty-six patients who received heart transplants between September 1998 and July 2000 were analyzed by intravascular ultrasound within 6 weeks and again at 12 months after transplantation. These patients were divided into 2 groups: the HBV Group (n = 13) in which either the donor or recipient was seropositive for hepatitis B core antibody (HBcAb), and a Control Group (n = 53) in which neither donor nor recipient was positive for HBcAb. Baseline characteristics of the 2 groups were similar. The HBV Group had significant increase in the change in average intimal area (1.59 +/- 1.4 vs 0.46 +/- 0.4 mm2, p = 0.01) per mm length of the vessel compared with controls. Allograft vasculopathy at 1 year (defined as largest maximal intimal thickness increase of > or =0.50 mm) occurred in 46% of the HBV group compared with 24% of the control group (p = 0.05). When measured...Continue Reading

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Citations

Jan 22, 2010·Transplantation·David S XuGonzalo V Gonzalez-Stawinski
Jun 5, 2007·Heart Failure Clinics·Ilke Sipahi, Randall C Starling
Dec 8, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Thorsten Wittwer, Thorsten Wahlers
Mar 23, 2013·Clinical Transplantation·Emanuele Durante-MangoniRiccardo Utili
Sep 14, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·N MahboobiS M Alavian
Sep 3, 2014·Nature Reviews. Nephrology·Jay A Fishman, Paolo A Grossi

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