Donor PPARα Gene Polymorphisms Influence the Susceptibility to Glucose and Lipid Disorders in Liver Transplant Recipients: A Strobe-Compliant Observational Study

Medicine
Qi LingShusen Zheng

Abstract

Peroxisome proliferator-activated receptor α (PPARα) is an important regulator of glucose and lipid metabolism, and is predominantly expressed in the liver. We aimed to evaluate the effect of donor hepatic PPARα gene polymorphisms on the development of metabolic disorders following liver transplantation (LT).A total of 176 patients undergoing primary LT were included in this Review Board-approved study. Genomic DNA was extracted from fresh frozen donor liver tissues (biopsy specimens for pathological testing at surgery). Eight single nucleotide polymorphisms in the PPARα gene were chosen from either the HapMap CHB database or previous reports.The distribution of metabolic disorders differed significantly between the wild-type and variant genotypes of both the rs5767743 and rs5767700 loci (P < 0.05 for all). After an adjustment for other factors (body mass index and tacrolimus blood concentration), the rs5767743 genetic variant was found to be an independent protective factor (P = 0.005, odds ratio = 0.416 per C allele, 95% confidence interval  = 0.225-0.768). When compared with the wild-type genotype, the variant genotypes rs5767743 and rs5767700 correlated with significantly increased PPARα and CYP3A4 mRNA expression and lower...Continue Reading

References

Aug 1, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marie LaryeaKevork M Peltekian
Feb 19, 2008·Journal of Clinical Gastroenterology·Richard H Moseley
May 22, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K D S WattM R Charlton
Jan 22, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ido LaishZiv Ben Ari
Nov 1, 2011·Journal of Hepatology·Kan NakagawaToshifumi Aoyama
Apr 19, 2012·Clinical Pharmacology and Therapeutics·Kathrin KleinUlrich M Zanger
Oct 2, 2012·PPAR Research·Marion PeyrouMichelangelo Foti
Jan 17, 2013·World Journal of Gastroenterology : WJG·Qi LingShu-Sen Zheng
Jun 20, 2013·Mediators of Inflammation·Francisco A MonsalveRodrigo Moore-Carrasco

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Citations

Jun 24, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G A RoccaroY-X Yang
Jul 28, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Q LingS Zheng
Oct 20, 2018·Transplantation·Giacomo GermaniKymberly D Watt
Jun 8, 2019·Clinical Transplantation·Sarah SchneiderMarina Berenguer
Oct 28, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Qi LingBaohong Wang
Sep 9, 2016·World Journal of Gastroenterology : WJG·Miguel Jiménez-PérezJuan Miguel Rodrigo López

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Methods Mentioned

BETA
PCR

Software Mentioned

SDS
SNPStats
SPSS
Haploview

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