Donor safety and plasma quality in automated plasmapheresis. Comparison of two filter materials

Vox Sanguinis
B AeschbacherU E Nydegger

Abstract

The level of blood cells and differential counts as well as of selected clotting and complement system components and breakdown products were measured in donor plasma of 42 polycarbonate filter (group I) and 7 nylon filter (group II) plasmapheresis procedures. Three different sampling time points were considered: (1) 1 min prior to connecting the donor to the machine (sample A); (2) 1 min after donation by a repeat venipuncture (sample B), and (3) in collected plasma (sample C). The better biocompatibility of the newly introduced nylon filters became evident on the basis of blood cell counts with significant drops of total white blood cell counts, monocytes, lymphocytes and platelets in sample B of group I, but not of group II. Similarly, complement studies revealed significant decrease of CH 50, C4 and C3 in samples B and C of group I, but only in samples C of group II. Coagulation studies showed significant increases of fibrinopeptide A and beta-thromboglobulin in samples B and C of group I; in group II beta-thromboglobulin was significantly increased in sample C compared to sample A. Plasminogen levels were decreased in samples B and C of group I but not of group II. Nonactivated partial thromboplastin time remained normal i...Continue Reading

References

Aug 19, 1976·The New England Journal of Medicine·H L Nossel
Aug 1, 1977·Thrombosis Research·V Hofmann, P W Straub
Apr 1, 1985·Seminars in Thrombosis and Hemostasis·J SoriaM M Samama
Jan 1, 1986·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·K SmetanaH Busch
Jan 1, 1986·Blood Purification·M E De BroeW De Backer
Jan 1, 1986·Acta Haematologica·N A LeveneD Buskila
May 1, 1986·Transfusion·G RockN McCombie
Jan 1, 1986·Blood Purification·L W HendersonP Konstantin
Mar 25, 1968·JAMA : the Journal of the American Medical Association·L S Kaplow, J A Goffinet
Jan 1, 1983·Vox Sanguinis·R Pflugshaupt, G Kurt
Dec 1, 1981·Thrombosis Research·S P LevineN M Raymond

Citations

Nov 3, 1996·Transfusion Science·U E NydeggerB Lämmle
Apr 18, 2013·Transplantation·Mahmoud SadeghiGerhard Opelz
Feb 11, 2012·Seminars in Dialysis·Andre Kaplan
Nov 4, 1994·Transfusion Science·J K Smith
Dec 10, 1989·Transfusion Science·U E NydeggerB Aeschbacher

Related Concepts

Polycarbonate R2200
Beta-2 Thromboglobulin
Complete Blood Count
Blood Coagulation Tests
Blood Donor
Hemolytic Complement
Fibrinopeptide A
Filtration
Hematologic Tests
Supramid

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