Donor-specific antibodies after pediatric liver transplantation: a cross-sectional study of 50 patients

Transplant International : Official Journal of the European Society for Organ Transplantation
Jesper M KiveläJouni Lauronen

Abstract

The role of donor-specific HLA antibodies (DSAs) after pediatric liver transplantation (LT) is inadequately established. We conducted a cross-sectional study on the prevalence of DSAs and their association with liver histology and biochemical variables after pediatric LT. Serum samples were drawn for HLA antibody analyses from 50 patients (76% of 66 eligible patients) operated on at age <18 years between 1987 and 2007 with a median of 10.0 (interquartile range 4.0-16.4) years after deceased donor LT. Mixed and single-antigen beads with Luminex were used for HLA antibody screening and detection. A mean fluorescence intensity (MFI) value of 1000 was used for positive cutoff. Twenty-six patients (52%; 95% confidence interval (CI) 39% to 65%) had DSAs. In 22 (85%) patients, DSAs were against class II HLA antigens with a mean (standard deviation) MFI of 13,481 (4727). The unadjusted prevalence ratio for portal inflammation in DSA-positive compared to DSA-negative patients (n = 47; 9/24 vs. 1/23) was 8.6 (95% CI 1.6 to 50.9). Laboratory values at the time of study were comparable between DSA-positive and DSA-negative patients. In conclusion, approximately half of patients studied had DSAs after pediatric LT. Portal inflammation was a...Continue Reading

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Citations

Oct 27, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Deirdre KellyStefan Hübscher
Jul 15, 2017·Current Opinion in Organ Transplantation·Russell N WessonJacqueline Garonzik-Wang
Aug 19, 2020·Journal of Pediatric Gastroenterology and Nutrition·Emma Monique SaelensRuth M L De Bruyne
Apr 29, 2021·Journal of Pediatric Gastroenterology and Nutrition·Juliane K GötzUlrich Baumann
Jul 10, 2021·World Journal of Hepatology·Felicitas Leonie SchottersEnke Freya Grabhorn

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