Donor-specific B and T lymphocyte antibodies and kidney graft survival

Transplantation
M JeannetI Arni

Abstract

The prognostic significance of a positive B and/or T cell crossmatch test before transplantation was analysed in 174 cadaver kidney transplants. Thirty-one B cell-positive crossmatches were observed. In 15 of these cases, T cell crossmatches were also found to be positive retrospectively (long incubation assays). In 16 patients with a positive B cell crossmatch, an anti-HLA-DR antibody was present, as judged by platelet absorption studies, whereas in the other patients the B cell activity of the sera was attributable to weak anti-HLA-A,B,C antibodies or to cold autoantibodies. The success rate at 3 months of positive B cell crossmatch transplants because of anti-HLA-A,B,C or anti-HLA-DR antibodies was 84% whereas that of grafts with negative B and T cells crossmatches was 79%. Patients with B cell autoantibodies had excellent graft survival. Serial serum samples from patients receiving transplants were tested against specific donor B and T cells kept frozen. B cell antibodies appeared or persisted in 38 of 44 patients tested. Many patients also had donor T cell antibodies. Platelet absorption studies showed that about one-half of the B cell antibodies were presumably anti-HLA-DR and one-half anti-HLA-A,B,C. Donor-specific anti-...Continue Reading

Citations

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