Donor stem cell infusion after non-myeloablative conditioning for tolerance induction to HLA mismatched adult living-donor liver graft

Transplant Immunology
V DonckierM Goldman

Abstract

The induction of transplantation tolerance, defined as the survival of a functioning allograft in the absence of continuing immunosuppressive therapy, would be a major advance. Clinical and experimental data have shown that transplantation tolerance could be induced by pre-transplant myeloconditioning and infusion of donor hematopoietic cells. We investigated the feasibility and safety of a protocol to induce tolerance to HLA mismatched living-donor liver graft by pre-transplant non-myeloablative conditioning followed by donor stem cells (SC) infusion, in patients with advanced liver cancers. Two patients with intrahepatic cancers who did not fulfill criteria for cadaver liver transplantation were included in the study. Preparative regimen consisted in cyclophosphamide and anti-thymocyte globulin, followed by infusion of purified donor CD34(+) stem cells. Living-donor liver transplantation (LDLT) using the liver right lobe was performed after hematological reconstitution, respectively 40 and 55 days after donor stem cell infusion. Immunosuppressive therapies were discontinued when liver graft function returned to normal. The procedure could be completed in the two patients. No severe toxicity of the preparative regimen was obse...Continue Reading

References

Mar 14, 1996·The New England Journal of Medicine·V MazzaferroL Gennari
Jan 27, 1997·Transplantation·G V MazariegosT E Starzl
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J DevlinR Williams
Dec 4, 2001·Journal of Immunological Methods·Patrick StordeurMichel Goldman
May 16, 2002·Blood·Terry J Fry, Crystal L Mackall
May 10, 2003·Journal of Immunological Methods·Patrick StordeurMichel Goldman
Sep 26, 2003·Transplantation·Zakiyah KadryPierre-Alain Clavien

❮ Previous
Next ❯

Citations

Oct 10, 2013·World Journal of Gastroenterology : WJG·Sheng-Li Wu, Cheng-En Pan
Jan 25, 2008·The New England Journal of Medicine·Stephen I AlexanderMichael O Stormon
Oct 29, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Thomas Fehr, Megan Sykes
Mar 9, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Josh Levitsky
May 17, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Isabelle ColleHans Van Vlierberghe
Sep 1, 2015·Methods : a Companion to Methods in Enzymology·Christopher D PoradaGraça Almeida-Porada
Apr 28, 2009·Journal of Hepatology·Giuseppe OrlandoKathryn Wood
Aug 12, 2008·Experimental Cell Research·Kai-Hsin ChangThalia Papayannopoulou
Sep 17, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Pierluigi ToniuttoPatrizia Burra
Sep 28, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Vincent DonckierMichel Goldman
Mar 19, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Olivia M Martinez, Hugo R Rosen
Jul 16, 2010·Current Opinion in Organ Transplantation·Laurence A TurkaJeffrey A Bluestone
Sep 3, 2010·Nature Reviews. Nephrology·Nina Pilat, Thomas Wekerle
Oct 12, 2018·Minerva gastroenterologica e dietologica·Pierluigi ToniuttoElisa Fumolo
Oct 29, 2010·Expert Review of Clinical Immunology·Giuseppe Orlando
Nov 8, 2017·Human Vaccines & Immunotherapeutics·Inga HochnadelTetyana Yevsa
Dec 29, 2015·Current Opinion in Organ Transplantation·Sandy Feng
Jul 17, 2020·Frontiers in Immunology·Xiaoxiao DuZhonghua Klaus Chen
Aug 8, 2020·Nature Reviews. Gastroenterology & Hepatology·Angus W ThomsonAlberto Sanchez-Fueyo
Mar 7, 2021·International Journal of Molecular Sciences·Filip CvetkovskiErik Berglund

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
V DonckierM Goldman
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Ying LiKoichi Tanaka
© 2021 Meta ULC. All rights reserved