Dopamine-2 receptors in the arcuate nucleus modulate cocaine-seeking behavior

Ravid DoronGal Yadid


Beta-endorphin is an endogenous opioid peptide, implicated in the behavioral effects of drugs of abuse. It is synthesized in the arcuate nucleus and secreted into the nucleus accumbens. In the present study, we examined the interaction between arcuate nucleus dopaminergic cells and accumbal beta-endorphin, during cocaine exposure. Using microdialysis, we found that blockade of arcuate dopamine-2 receptors with a selective antagonist significantly attenuated cocaine-induced increases of beta-endorphin levels in the nucleus accumbens. Moreover, rats chronically exposed to cocaine using the self-administration paradigm displayed extinction-like behavior following blockade of dopamine-2 receptors. These findings indicate that dopaminergic neurons in the arcuate nucleus may induce the secretion of beta-endorphin in the nucleus accumbens, and that they are implicated in the cocaine reward pathway.


Sep 21, 1978·Nature·S J WatsonJ D Barchas
Jun 28, 1992·Annals of the New York Academy of Sciences·T S ShippenbergC Stein
Jul 1, 1991·Trends in Neurosciences·M J KuharJ W Boja
Mar 1, 1984·Pharmacology, Biochemistry, and Behavior·N E GoedersJ E Smith
Apr 15, 1982·Brain Research·M E Olds
Aug 12, 1999·European Journal of Pharmacology·G Di Chiara
Mar 26, 2003·The European Journal of Neuroscience·Abraham Zangen, Uri Shalev
Nov 26, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Mirjam A F M GerritsJan M van Ree
Apr 20, 2004·Neuroreport·Ilana Roth-DeriGal Yadid
Jul 27, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ilana Roth-DeriGal Yadid


Mar 13, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Diana Simmons, David W Self
Jan 29, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David ErritzoeAnne R Lingford-Hughes
Apr 10, 2012·Neuropeptides·K P GudehithluMaria Hadjiconstantinou
Mar 6, 2012·Biological Psychiatry·Alessandro ColasantiEugenii A Rabiner
Apr 5, 2016·Depression Research and Treatment·Luigi Grillo
Nov 11, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Inge MickAnne R Lingford-Hughes
Jul 8, 2008·Progress in Neurobiology·Ilana Roth-DeriGal Yadid
Oct 24, 2007·Peptides·Richard J Bodnar
Feb 6, 2018·Neurochemical Research·Irina V RomanovaAlexander O Shpakov
Mar 30, 2018·Schizophrenia Research and Treatment·Luigi Grillo

Related Concepts

A 38503
Structure of Nucleus Infundibularis Hypothalami
Behavior, Animal
Cocaine Hydrochloride
Reinforcement Schedule
Self Administration
Rats, Holtzman
Dopamine D2 Receptor

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.