Dopamine-2 receptors in the arcuate nucleus modulate cocaine-seeking behavior

Neuroreport
Ravid DoronGal Yadid

Abstract

Beta-endorphin is an endogenous opioid peptide, implicated in the behavioral effects of drugs of abuse. It is synthesized in the arcuate nucleus and secreted into the nucleus accumbens. In the present study, we examined the interaction between arcuate nucleus dopaminergic cells and accumbal beta-endorphin, during cocaine exposure. Using microdialysis, we found that blockade of arcuate dopamine-2 receptors with a selective antagonist significantly attenuated cocaine-induced increases of beta-endorphin levels in the nucleus accumbens. Moreover, rats chronically exposed to cocaine using the self-administration paradigm displayed extinction-like behavior following blockade of dopamine-2 receptors. These findings indicate that dopaminergic neurons in the arcuate nucleus may induce the secretion of beta-endorphin in the nucleus accumbens, and that they are implicated in the cocaine reward pathway.

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Citations

Mar 13, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Diana Simmons, David W Self
Jan 29, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David ErritzoeAnne R Lingford-Hughes
Apr 10, 2012·Neuropeptides·K P GudehithluMaria Hadjiconstantinou
Mar 6, 2012·Biological Psychiatry·Alessandro ColasantiEugenii A Rabiner
Apr 5, 2016·Depression Research and Treatment·Luigi Grillo
Nov 11, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Inge MickAnne R Lingford-Hughes
Jul 8, 2008·Progress in Neurobiology·Ilana Roth-DeriGal Yadid
Oct 24, 2007·Peptides·Richard J Bodnar
Feb 6, 2018·Neurochemical Research·Irina V RomanovaAlexander O Shpakov
Mar 30, 2018·Schizophrenia Research and Treatment·Luigi Grillo

Related Concepts

A 38503
Structure of Nucleus Infundibularis Hypothalami
Behavior, Animal
Beta-Endorphin
Cocaine Hydrochloride
Reinforcement Schedule
Salicylamides
Self Administration
Rats, Holtzman
Dopamine D2 Receptor

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