Dopamine activates the motor pattern for crawling in the medicinal leech.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Joshua G Puhl, K A Mesce

Abstract

Locomotion in segmented animals is thought to be based on the coupling of "unit burst generators," but the biological nature of the unit burst generator has been revealed in only a few animal systems. We determined that dopamine (DA), a universal modulator of motor activity, is sufficient to activate fictive crawling in the medicinal leech, and can exert its actions within the smallest division of the animal's CNS, the segmental ganglion. In the entire isolated nerve cord or in the single ganglion, DA induced slow antiphasic bursting (approximately 15 s period) of motoneurons known to participate in the two-step elongation-contraction cycle underlying crawling behavior. During each cycle, the dorsal (DE-3) and ventral (VE-4) longitudinal excitor motoneurons fired approximately 180 degrees out of phase from the ventrolateral circular excitor motoneuron (CV), which marks the elongation phase. In many isolated whole nerve cords, DE-3 bursting progressed in an anterior to posterior direction with intersegmental phase delays appropriate for crawling. In the single ganglion, the dorsal (DI-1) and ventral (VI-2) inhibitory longitudinal motoneurons fired out of phase with each DE-3 burst, further confirming that the crawl unit burst ge...Continue Reading

References

Oct 1, 1986·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·P D Brodfuehrer, W O Friesen
Apr 1, 1986·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·W Stern-TomlinsonW B Kristan
Mar 20, 1983·The Journal of Comparative Neurology·R M Robertson, K G Pearson
Nov 1, 1995·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·B A O'Gara, W O Friesen
Jul 1, 1995·Journal of Neurobiology·P D BrodfuehrerW O Friesen
Feb 3, 1999·Annals of the New York Academy of Sciences·K A Sigvardt, W L Miller
Jun 9, 2000·Annual Review of Physiology·K G Pearson
Oct 4, 2000·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·F J EisenhartW B Kristan
Nov 21, 2000·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·C G HockerW O Friesen
Feb 13, 2001·Progress in Neurobiology·P D Brodfuehrer, M S Thorogood
Dec 26, 2001·The Journal of Comparative Neurology·Kevin M CrispKaren A Mesce
May 22, 2003·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·K M Crisp, K A Mesce
Aug 9, 2003·Journal of Neurophysiology·Andrew A V HillRonald L Calabrese
Mar 16, 2004·The European Journal of Neuroscience·Grégory BarrièreJean-René Cazalets
Dec 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Masahiro MatsunagaKazuyoshi Tsutsui
Nov 2, 2005·Progress in Neurobiology·William B KristanW Otto Friesen
Sep 26, 2006·Journal of Computational Neuroscience·M ZhengT Iwasaki
Oct 20, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kevin L Briggman, William B Kristan
May 18, 2007·Journal of Neurophysiology·Brian Mulloney, Wendy M Hall
Jun 15, 2007·Developmental Neurobiology·Kaneyasu NishimuraKiyokazu Agata

❮ Previous
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Citations

Feb 6, 2010·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Michael J BaltzleyWilliam B Kristan
Dec 20, 2011·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·C Bernardo Perez-EtchegoyenLidia Szczupak
Mar 2, 2012·Journal of Neurophysiology·Olivia J Mullins, W Otto Friesen
Feb 15, 2012·Neural Systems & Circuits·Damon G Lamb, Ronald L Calabrese
Dec 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joshua G PuhlKaren A Mesce
Feb 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joshua G Puhl, Karen A Mesce
Dec 5, 2013·Journal of Visualized Experiments : JoVE·Josh TitlowRobin L Cooper
Feb 20, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Kevin M CrispXong Yang
Dec 1, 2009·Journal of Insect Physiology·Julie A MustardBrian H Smith
Jun 1, 2011·Current Opinion in Neurobiology·Chris R Palmer, William B Kristan
Jul 2, 2014·Frontiers in Neural Circuits·Simon A SharplesPatrick J Whelan
Aug 28, 2016·Journal of Chemical Neuroanatomy·Adejoke Y OnaolapoPolycarp U Nwoha
Feb 16, 2018·The Journal of Experimental Biology·Karen A MesceJoshua G Puhl
Feb 6, 2019·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Rachel C KimDavid A Weisblat
Oct 6, 2009·Nature Neuroscience·Quentin Gaudry, William B Kristan
Jan 13, 2012·Journal of Neurophysiology·Mariano J RodriguezLidia Szczupak
Mar 20, 2015·Journal of Neurophysiology·Cynthia M HarleyKaren A Mesce
Aug 28, 2015·Journal of Neurophysiology·Stefan R PulverBerthold Hedwig
Mar 18, 2011·Journal of Neurophysiology·Giacomo Bisson, Vincent Torre
Feb 26, 2020·Journal of Neuroscience Research·Oliva Mota SeguraMichael W Baker
Dec 10, 2016·Ecotoxicology·Jade DrummondSarah J Judge
Jun 21, 2013·The Journal of Experimental Biology·Cynthia M HarleyDaniel Wagenaar
Jun 5, 2012·The Journal of Experimental Biology·Kevin M CrispKaren A Mesce
Jun 7, 2014·The Journal of Experimental Biology·Chris R PalmerWilliam B Kristan
May 13, 2021·Journal of Neurophysiology·Virginia Comas, Michel Borde
Dec 16, 2020·Biochemical and Biophysical Research Communications·Björn Brembs
May 27, 2021·Integrative and Comparative Biology·Charlotte L BarkanErik Zornik

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