Dopamine agonist treatment of Tourette disorder in children: results of an open-label trial of pergolide

Movement Disorders : Official Journal of the Movement Disorder Society
J F LipinskiG Sethuraman

Abstract

This exploratory study was meant to determine the effect of the dopamine (DA) agonist pergolide on Gilles de la Tourette syndrome (GTS) in children and adolescents and to ascertain correlates of pergolide response. Thirty-two outpatients, aged 7-19 years, were systemically assessed in a neuropsychiatric clinic for the presence of GTS and comorbid disorders. After a 6-week open-label, fixed-flexible dosing schedule, response to pergolide on standard GTS severity outcome measures was assessed. Overall, 75% of patients (24/32) had a > 50% drop in their tic severity rating from baseline with a mean treatment dosage of 177 +/- 61 micrograms/day. Highly significant (p = 0.0001) baseline to week 6 differences were demonstrated in all tic symptom measures. The presence of restless legs syndrome (RLS) comorbidity (59%) was highly associated with a positive response. These results suggest DA agonism as a strategy, and pergolide in particular, may be a practical form of therapy for GTS. Response predictors of patient comorbid RLS argue for its further study with regard to GTS.

References

Aug 1, 1979·Archives of General Psychiatry·M Feinberg, B J Carroll
Jan 1, 1991·Movement Disorders : Official Journal of the Movement Disorder Society·A S WaltersS Chokroverty
Jan 1, 1991·Life Sciences·R W Fuller, J A Clemens
Apr 1, 1991·Archives of General Psychiatry·J F LeckmanD J Cohen
Nov 1, 1989·Archives of General Psychiatry·W K GoodmanD S Charney
Nov 1, 1989·Archives of General Psychiatry·W K GoodmanD S Charney
Jul 1, 1989·Journal of the American Academy of Child and Adolescent Psychiatry·J F LeckmanD J Cohen
Oct 1, 1982·Annals of Neurology·H S SingerJ T Coyle
Mar 1, 1984·Journal of the American Academy of Child Psychiatry·D F HarcherikD J Cohen
May 1, 1980·Clinical Pharmacology and Therapeutics·L LembergerJ T Callaghan
Oct 1, 1994·Pediatric Neurology·A S WaltersM L Wagner
Jun 1, 1994·Acta Neurologica Scandinavica·N MüllerA Straube
Sep 1, 1993·Journal of the American Academy of Child and Adolescent Psychiatry·D L PaulsD J Cohen
Sep 1, 1995·Movement Disorders : Official Journal of the Movement Disorder Society·A S Walters
Feb 19, 1998·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·H J Jones, J K Derodra
Oct 1, 1993·Journal of Child and Adolescent Psychopharmacology·R R SilvaA J Friedhoff

❮ Previous
Next ❯

Citations

Dec 5, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·H S Singer
Dec 5, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·K J Black, J W Mink
Jan 5, 2001·European Child & Adolescent Psychiatry·M M Robertson, J S Stern
Mar 20, 2002·Current Neurology and Neuroscience Reports·H S Singer
Jul 17, 2008·Current Psychiatry Reports·Michael H Bloch
Nov 30, 2000·Current Treatment Options in Neurology·R D BuzanC Schneck
Mar 24, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Lawrence ScahillJohn Walkup
Jul 5, 2003·Journal of Psychosomatic Research·Paul Sandor
Dec 22, 1999·Pharmacology & Therapeutics·G EmilienS Cragg
Feb 26, 2004·Brain & Development·Yoshiko Nomura, Masaya Segawa
Aug 22, 2002·Journal of Child and Adolescent Psychopharmacology·Thomas OwleyEdwin H Cook
Sep 3, 2010·Journal of Child and Adolescent Psychopharmacology·Steve W WuDonald L Gilbert
Jul 23, 2003·Journal of the American Academy of Child and Adolescent Psychiatry·Floyd R SalleeKeith Wilner
Sep 22, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L VignatelliUNKNOWN EFNS Task Force
Jul 23, 1999·Annals of the New York Academy of Sciences·N R SwerdlowM A Geyer
Feb 23, 2011·Therapeutic Advances in Neurological Disorders·Clare M EddyAndrea E Cavanna
Jan 5, 2002·Drugs·F J Jiménez-Jiménez, P J García-Ruiz
Jun 8, 2001·Paediatric Drugs·E H Kossoff, H S Singer
Apr 6, 2006·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Cindy ZadikoffAnthony Lang
Aug 2, 2007·Journal of the American Academy of Child and Adolescent Psychiatry·James E SwainJames F Leckman
Sep 17, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·P LespéranceUNKNOWN Montréal Tourette Study Group
Mar 13, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Roger KurlanUNKNOWN Pramipexole for TS Trial Investigators
Mar 13, 2010·Annals of Neurology·Thomas D L SteevesAntonio P Strafella
Jun 27, 2002·Expert Opinion on Pharmacotherapy·Kirsten R Müller-Vahl
Oct 23, 2012·Neuroscience and Biobehavioral Reviews·Judith BuseVeit Roessner
Sep 6, 2008·Progress in Brain Research·Thomas D L Steeves, Susan H Fox
May 26, 1999·Journal of Child Neurology·Y Awaad
Mar 8, 2011·British Journal of Hospital Medicine·Mary M Robertson
Nov 18, 2009·Nature Reviews. Nephrology·Hartmut H MallucheJohann Herberth
Sep 2, 1998·Current Opinion in Neurology·M M Robertson, J S Stern
Apr 9, 2005·Current Treatment Options in Neurology·Donald L Gilbert, Tara D Lipps

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

© 2021 Meta ULC. All rights reserved