PMID: 7520178Aug 16, 1994Paper

Dopamine alters glutamate receptor desensitization in retinal horizontal cells of the perch (Perca fluviatilis)

Proceedings of the National Academy of Sciences of the United States of America
K F SchmidtH Hatt

Abstract

The patch-clamp technique in combination with a fast liquid filament application system was used to study the effect of dopamine on the glutamate receptor desensitization in horizontal cells of the perch (Perca fluviatilis). Kinetics of ligand-gated ion channels in fish horizontal cells are modulated by dopamine. This modulation is presumably mediated by a cAMP-dependent protein phosphorylation. Before incubation with dopamine, the glutamate receptors of horizontal cells activate and desensitize with fast time constants. In the whole-cell recording mode, fast application of the agonists L-glutamate, quisqualate, or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid prior to the dopamine incubation gives rise to fast transient currents with peak values of about 200 pA that desensitize within 100 ms. Kainate as agonist produced higher steady-state currents but no transient currents. After incubation of the cells with dopamine for 3 min, the desensitization was significantly reduced and the agonists L-glutamate, quisqualate, or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid induced steady-state currents with amplitudes that were similar to the previously observed transient currents. Kainate-induced currents were on...Continue Reading

References

Feb 1, 1992·Neurochemistry International·J C Besharse, P M Iuvone
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J S Isaacson, R A Nicoll
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Citations

Apr 29, 1998·European Journal of Pharmacology·J L Do NascimentoF G De Mello
Apr 20, 2001·Neuroscience Research·H HirasawaM Yamada
Feb 25, 2003·Progress in Retinal and Eye Research·Gilad TwigIdo Perlman
Oct 26, 1999·Progress in Retinal and Eye Research·W B Thoreson, P Witkovsky
Jan 1, 1997·Visual Neuroscience·S Eliasof, C E Jahr
Jun 18, 1999·British Journal of Pharmacology·N G CastroY Aracava
Dec 18, 1998·Neuron·H von GersdorffM Tachibana
Apr 29, 2008·Vision Research·Renate PflugHerbert Reitsamer
Sep 3, 2002·Journal of Neurophysiology·Dao-Qi ZhangDouglas G McMahon

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