PMID: 6164062Dec 1, 1980Paper

Dopamine and depolarizing agents regulate the state of phosphorylation of protein I in the mammalian superior cervical sympathetic ganglion

Proceedings of the National Academy of Sciences of the United States of America
E J Nestler, P Greengard

Abstract

The regulation of the state of phosphorylation of protein I, a specific neuronal protein that appears to be associated predominantly with synaptic vesicles, has been studied in intact sections of bovine superior cervical ganglion. For this purpose, a technique was developed that made possible the quantitation of the state of phosphorylation of as little as 5 fmol of protein I. Incubation of ganglion sections in the presence of dopamine, 8-bromo-cyclic AMP, or depolarizing agents (i.e., high K+ concentration or veratridine) increased the state of phosphorylation of protein I relative to that of control ganglion sections. Other results indicated that the effect of dopamine is probably mediated via the activation of a cyclic AMP-dependent protein kinase and that the effect of high K+ concentration is probably mediated via the activation of a calcium-dependent protein kinase.

References

Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J Forn, P Greengard
Jan 1, 1978·Annual Review of Pharmacology and Toxicology·O Eränkö
May 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·W SieghartP Greengard
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·W B Huttner, P Greengard
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P De CamilliP Greengard
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·F E BloomP Greengard

❮ Previous
Next ❯

Citations

Dec 15, 1986·Biochemical Pharmacology·P De Camilli, P Greengard
Aug 1, 1982·Pharmacology, Biochemistry, and Behavior·R JorkH Matthies
Aug 1, 1989·Neuron·B W Bernstein, J R Bamburg
Oct 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Mattias SjöströmAlejandro M Bertorello
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S E GoelzP Greengard
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K Tsou, P Greengard
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·G FriedP Greengard
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R LlinásP Greengard
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T Saitoh, K R Dobkins
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K D ParfittM D Browning
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S Y NahZ Vogel
Jun 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M BählerP Greengard
Mar 1, 1984·Journal of Neurochemistry·R G Sorensen, J A Babitch
Nov 1, 2016·Journal of Neurochemistry·J David Sweatt
Jan 9, 1986·Nature·A J Baines, V Bennett
Apr 1, 1987·Reviews in the Neurosciences·J L Waddington, K M O'Boyle
Oct 13, 1983·Nature·E J Nestler, P Greengard
Jan 1, 1987·Molecular Neurobiology·P Greengard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
W B Huttner, P Greengard
Proceedings of the National Academy of Sciences of the United States of America
P De CamilliP Greengard
© 2021 Meta ULC. All rights reserved