Dopamine and Huntington's disease

Expert Review of Neurotherapeutics
Laetitia C SchwabRoger A Barker

Abstract

Huntington's disease (HD) is an incurable, inherited, progressive neurodegenerative disorder that is defined by a combination of motor, cognitive and psychiatric features. Pre-clinical and clinical studies have demonstrated an important role for the dopamine (DA) system in HD with dopaminergic dysfunction at the level of both DA release and DA receptors. It is, therefore, not surprising that the drug treatments most commonly used in HD are anti-dopaminergic agents. Their use is based primarily on the belief that the characteristic motor impairments are a result of overactivation of the central dopaminergic pathways. While this is a useful starting place, it is clear that the behavior of the central dopaminergic pathways is not fully understood in this condition and may change as a function of disease stage. In addition, how abnormalities in dopaminergic systems may underlie some of the non-motor features of HD has also been poorly investigated and this is especially important given the greater burden these place on the patients' and families' quality of life. In this review, we discuss what is known about central dopaminergic pathways in HD and how this informs us about the mechanisms of action of the dopaminergic therapies use...Continue Reading

References

Jul 1, 1976·Archives of Neurology·R KartzinelD B Calne
Oct 1, 1976·Journal of Neurology, Neurosurgery, and Psychiatry·C LoebC Albano
Jul 15, 1976·Life Sciences·M TrabucchiL Frattola
Oct 1, 1989·Trends in Neurosciences·R L AlbinJ B Penney
Dec 1, 1987·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·P SeemanW W Tourtellotte
Nov 1, 1985·Journal of Neuropathology and Experimental Neurology·J P VonsattelE P Richardson
Oct 1, 1985·Neurology·W C Koller, J Trimble
Jun 1, 1987·Journal of Pharmaceutical Sciences·R Mehvar, F Jamali
Dec 5, 1970·Lancet·H C KlawansA Barbeau
Apr 22, 1972·Lancet·B K TanH J v d Brand
Mar 2, 1974·Lancet·G Schenk, H J Leijnse-Ybema
Aug 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·F GirottiT Caraceni
May 1, 1983·Journal of the Neurological Sciences·L FrattolaM Trabucchi
Aug 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·N Quinn, C D Marsden
Jan 1, 1980·Annual Review of Pharmacology and Toxicology·E D Bird
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·J D EricksonE Weihe
Jul 1, 1997·Journal of Neurology, Neurosurgery, and Psychiatry·J P van VugtR A Roos
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·J H ChaA B Young
Oct 8, 1998·The New England Journal of Medicine·A E Lang, A M Lozano
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·O HanssonP Brundin
Dec 3, 1999·Brain : a Journal of Neurology·T C AndrewsD J Brooks
Jan 25, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·I ReuterK R Chaudhuri
Feb 2, 2000·Neuroscience and Biobehavioral Reviews·D ValloneE Borrelli
May 10, 2000·Neurology·N I BohnenR L Albin
Oct 4, 2000·Physiological Reviews·M E FreemanG Nagy
Mar 14, 2002·International Clinical Psychopharmacology·R M BonelliP Költringer
May 25, 2002·Acta Neurologica Scandinavica·D PaleacuN Giladi

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Citations

Nov 5, 2015·Expert Opinion on Pharmacotherapy·Sarah L Mason, Roger A Barker
Feb 18, 2016·Expert Opinion on Investigational Drugs·Kathleen M Shannon
Aug 19, 2016·Expert Review of Neurotherapeutics·E UntiR Ceravolo
Sep 23, 2016·PloS One·Ruth de Diego-BalaguerUNKNOWN French Speaking Huntington Group
Dec 9, 2016·Expert Opinion on Investigational Drugs·Thomas Müller
Jun 8, 2017·Brain Sciences·Ryoma Morigaki, Satoshi Goto
Dec 9, 2017·American Journal of Medical Genetics. Part a·Audrey S Dickey, Albert R La Spada
Dec 29, 2015·Journal of the International Neuropsychological Society : JINS·Nelleke C van WouweScott A Wylie
Oct 11, 2017·EMBO Molecular Medicine·Melanie AlpaughSimonetta Sipione
Dec 19, 2016·Drugs·Emma M Coppen, Raymund A C Roos
Feb 27, 2018·Journal of Huntington's Disease·Susanna WatersNicholas Waters
Jan 12, 2019·Neurotoxicity Research·Musthafa Mohamed EssaMohammed Akbar
Nov 3, 2020·Journal of Clinical Psychopharmacology·Giovanni PalermoRoberto Ceravolo
Nov 5, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Anand Kumar Sahu, Ashok Kumar Mishra

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