Dopamine and memory: modulation of the persistence of memory for novel hippocampal NMDA receptor-dependent paired associates.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Ingrid BethusRichard G M Morris

Abstract

Three experiments investigated the role in memory processing of dopamine (DA) afferents to the hippocampus (HPC) that arise from the ventral tegmental area. One hypothesis is that D(1)/D(5) receptor activation in HPC is necessary for the encoding of novel, episodic-like information; the other is that DA activation ensures the greater temporal persistence of transient hippocampal memory traces. Rats (n = 35) were trained, in separate experiments using an episodic-like memory task, to learn six paired associates (PAs) in an "event arena" involving a repeated association between specific flavors of food and locations in space. After 6 weeks of training, rats had learned a "schema" such that two new paired associates could be acquired in a single trial in one session (episodic-like memory). We show that encoding of novel PAs is sensitive to intrahippocampal microinfusion of the NMDA antagonist d-AP-5. Experiment 1 established that intrahippocampal infusion of the D(1)/D(5) dopaminergic antagonist SCH23390 [R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride] before encoding of new PAs caused impaired memory 24 h later but that SCH23390 had no effect on the later memory of previously establish...Continue Reading

Citations

Mar 2, 2011·Psychopharmacology·Raquele Kipper MarianiMaribel Antonello Rubin
Dec 6, 2012·Nature Communications·K L ShiresS J Martin
Sep 25, 2012·Nature Neuroscience·Sarah RuedigerPico Caroni
Oct 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Szu-Han WangRichard G M Morris
Jul 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Diego MoncadaHaydee Viola
Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tomonori TakeuchiRichard G M Morris
Jul 9, 2011·Science·Dorothy TseRichard G M Morris
Oct 17, 2012·Journal of Cognitive Neuroscience·Sonia DoalloAnna Christina Nobre
Oct 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rumana ChowdhuryEmrah Düzel
May 4, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Caroline C Smith, Robert W Greene
Nov 2, 2012·Brain : a Journal of Neurology·Elizabeth J CoulthardAlan L Whone
Oct 8, 2013·Animal Cognition·Ragen T S McGowanLinda J Keeling
Jan 12, 2013·Cerebral Cortex·Nico BunzeckEmrah Duzel
May 3, 2014·Journal of Neurotrauma·Catherine WillmottRichard Burke
Jul 27, 2014·Neurobiology of Learning and Memory·S V TrossbachC Mattern
Oct 20, 2014·Nature Neuroscience·Colin G McNamaraDavid Dupret
Oct 1, 2013·Social Cognitive and Affective Neuroscience·Daniel G DillonDiego A Pizzagalli
Dec 15, 2015·Neuroscience and Biobehavioral Reviews·Ewa A MiendlarzewskaSophie Schwartz
Aug 16, 2015·Trends in Neurosciences·Laura A AthertonJack R Mellor
Apr 10, 2012·Neuroscience and Biobehavioral Reviews·Peter S B Finnie, Karim Nader
Mar 9, 2012·Trends in Neurosciences·Marlieke T R van KesterenRichard N Henson
Aug 20, 2011·Trends in Neurosciences·John LismanEmrah Duzel
Feb 15, 2011·Brain Research Bulletin·Josh D Hawk, Ted Abel
Sep 11, 2010·Trends in Cognitive Sciences·Daphna Shohamy, R Alison Adcock
Apr 26, 2011·Current Biology : CB·John Rothwell
Jul 11, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Jennifer G GoldmanChristopher G Goetz
Feb 22, 2012·The European Journal of Neuroscience·Horst SchicknickWolfgang Tischmeyer
Nov 3, 2015·Nature Neuroscience·Zev B RosenSteven A Siegelbaum
Oct 7, 2015·Frontiers in Psychology·Daniel G Dillon
Jul 21, 2015·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Nicola M J EdelstynAndrew R Mayes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.