Dopamine and sexual behavior in the male rabbit

Pharmacology, Biochemistry, and Behavior
Anders AgmoJ L Contreras

Abstract

Male rabbits were treated with the dopamine releasing drug amphetamine or the dopamine D1/D2 receptor antagonist cis(Z)-flupenthixol. Amphetamine, 1 to 4 mg/kg, had no effect on sexual behavior. Flupenthixol, 2 mg/kg, reduced the proportion of rabbits that ejaculated and the number of ejaculations per test. Lower doses were ineffective. Castrated males were treated with both drugs at two intervals after castration, 19-21 and 27-29 days postcastration, respectively. Amphetamine was without effect while flupenthixol, 1 mg/kg, reduced sexual behavior at the test 19-21 days postcastration. At the second test, sexual behavior was almost completely absent in control animals. Therefore, no further reduction could be observed after treatment with flupenthixol. Another group of animals was castrated and given androgen replacement. Testosterone decanoate was injected once weekly at a dose of 3 mg/kg. This treatment maintained a stable, low sexual activity. In these animals, amphetamine was again ineffective whereas flupenthixol, 1 mg/kg, inhibited sexual behavior. Gross motor function was evaluated in a water escape test. Amphetamine was inactive, and the effective dose of flupenthixol was 10 mg/kg. This dose is far above the dose requir...Continue Reading

References

May 1, 1978·Physiology & Behavior·E PagliettiG L Gessa
Apr 1, 1977·The Journal of Endocrinology·C O Malmnäs
Sep 1, 1976·Physiology & Behavior·A Agmo
Mar 1, 1992·Pharmacology, Biochemistry, and Behavior·S M Pomerantz
Dec 1, 1992·Pharmacology, Biochemistry, and Behavior·M A Charles, M Y McGinnis
Nov 1, 1990·Pharmacology, Biochemistry, and Behavior·L L Scaletta, E M Hull
Feb 1, 1990·Pharmacology, Biochemistry, and Behavior·A Agmo, Z Picker
Jan 1, 1989·Journal of Neural Transmission·A Agmo, H Fernández
Jan 1, 1987·Journal of Neural Transmission·M M Foreman, J L Hall
Jun 19, 1985·European Journal of Pharmacology·A Agmo, R Paredes
Feb 11, 1986·European Journal of Pharmacology·H Szechtman
Jul 15, 1983·European Journal of Pharmacology·J Hyttel
Jan 1, 1984·Pharmacology, Biochemistry, and Behavior·L Napoli-FarrisG L Gessa
May 7, 1982·European Journal of Pharmacology·J B BeckerK A Lorenz
Jan 1, 1994·Journal of Neural Transmission. General Section·A AgmoJ L Contreras
Apr 25, 1994·Neuroscience Letters·L HernandezT Baptista
Mar 1, 1993·Clinical and Experimental Pharmacology & Physiology·H NaganumaI Fujii
Aug 7, 1998·Journal of Psychopharmacology·R G ParedesA Agmo

❮ Previous
Next ❯

Citations

Feb 16, 2013·Neurochemistry International·Amanda V SteckertJoão Quevedo
Oct 20, 2007·Behavioural Brain Research·Sharon RauceoElizabeth Rodriguez
Aug 7, 1998·Journal of Psychopharmacology·R G ParedesA Agmo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.