Dopamine antagonists alter response allocation but do not suppress appetite for food in rats: contrast between the effects of SKF 83566, raclopride, and fenfluramine on a concurrent choice task

Psychopharmacology
J D SalamoneJ E Aberman

Abstract

Dopamine is important for enabling organisms to overcome work-related response costs. One way of investigating this function has been with concurrent choice procedures using food reinforcement. In the present study, rats were given a choice between pressing a lever for preferred Bioserve pellets, or approaching and consuming a less-preferred laboratory chow that was concurrently available. In previous work with this task, dopamine antagonists and accumbens dopamine depletions decreased lever pressing but increased chow consumption. The present study assessed three drugs (two dopamine antagonists and one appetite suppressant) using the lever pressing/chow feeding task. Under baseline conditions, rats pressed the lever at high rates (1,300-1,500 responses) to obtain the preferred food, and little of the laboratory chow was eaten (1-2 g). Selective D1 and D2 antagonists (SKF 83566 and raclopride) reduced fixed ratio 5 lever pressing, but substantially increased chow consumption. In contrast, the serotonergic appetite suppressant fenfluramine reduced both lever pressing and chow consumption. With the dopamine antagonists, lever pressing and chow consumption were inversely correlated across treatments, while these two measures were ...Continue Reading

Citations

Jan 11, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Colin M StopperStan B Floresco
Mar 16, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amy Cecilia SandersXiaoxi Zhuang
Apr 4, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jeremy J Day, Regina M Carelli
Apr 6, 2004·BMC Neuroscience·Paul J Kruzich, David K Grandy
Sep 5, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Susana MingoteJohn D Salamone
Feb 25, 2014·Physiology & Behavior·Rozita H AnderbergKarolina P Skibicka
Jan 7, 2014·Biological Psychiatry·Eleanor H SimpsonChristoph Kellendonk
Dec 7, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eric J NunesJohn D Salamone
May 30, 2015·Pharmacology, Biochemistry, and Behavior·Samantha E YohnJohn D Salamone
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Oct 3, 2006·Behavioural Brain Research·Dorothée Domenger, Rainer K W Schwarting

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