Dopamine beta-hydroxylase -1021C>T association and Parkinson's disease.

Parkinsonism & Related Disorders
Owen A RossMatthew J Farrer

Abstract

A single nucleotide polymorphism in the promoter region of the dopamine beta-hydroxylase gene (DBH -1021C>T; rs1611115) is reported to regulate plasma enzyme activity levels. This variant has also been the focus of two large association studies in Parkinson's disease yielding conflicting results. We examined this association in four Caucasian patient-control series (n=2696). A modest protective association was observed in the Norwegian series (OR=0.81, p=0.03; n=1676), however, the effect was in the opposite direction in the Polish series (OR=2.01, p=0.01; n=224). No association was observed for DBH -1021C>T with disease susceptibility in the US and Irish series, or combining all four series (OR=0.91, p=0.16, n=2696). We observed a modest association between DBH -1021C>T and AAO in the combined series (p=0.01). Taken together, these findings indicate that DBH -1021C>T does not play a major role in the pathogenesis of Parkinson's disease.

References

Jan 29, 1999·Archives of Neurology·D J GelbS Gilman
Mar 24, 2005·Annals of Neurology·Jakob C MuellerThomas Gasser
Aug 10, 2006·JAMA : the Journal of the American Medical Association·Demetrius M MaraganoreUNKNOWN Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium
May 16, 2007·Annals of Neurology·Lani S ChunCyrus P Zabetian
Apr 17, 2008·Annals of Neurology·Owen A RossRuey-Meei Wu

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Citations

Feb 5, 2010·Autonomic Neuroscience : Basic & Clinical·Sandro SorrentinoStefano Favale
Oct 16, 2019·Journal of Neurochemistry·Eugene Gonzalez-Lopez, Kent E Vrana
May 14, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Peng ShaoJing-Xi Bao
Sep 7, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Shan KangHong Jiang

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