Jan 1, 1975

Dopamine-containing neurons of the substantia nigra and their terminals in the neostriatum

UCLA Forum in Medical Sciences
V M TennysonL Marco

Abstract

Tne ultrastructural and fluorescence histochemical characteristics of the mature rabbit substantia nigra and neostriatum have been reviewed as a frame of reference for the developmental study. Biochemical investigations were reported on neostriatal dopamine concentrations and the relative uptake and accumulation of 3H-dopamine by this tissue from fetal to adult stages, to provide quantitative data for correlation with the fluorexcence information. The development of the neurons of the substantia nigra and their axons which project to the neostriatum has been presented from their appearance at day 14 of gestation to their maturation in early postnatal life. The initial bipolar neuroblasts, which develop in the midline of the caudal mesencephalon, are fluorescent as soon as they emerge from the ependymal zone. Their fluorescent axons, which form the nigroneostriatal pathway, reach the telencephalon at day 16 of gestation and ramify extensively in the putamen by day 20, but do not enter the caudate nucleus until several days later. Some of the early fluorescent axonal profiles in the putamen are extremely large. Electron microscopic study of theis stage suggests that the large fluorescent profiles may correspond to axonal growth c...Continue Reading

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Mentioned in this Paper

Cell Motility
Lentiform Nucleus Structure
Immunofluorescence Microscopy
Substantia Nigra Structure
Cell Differentiation Process
Neural Pathways
Axon
Synapses
Electron Microscopy
Morphogenesis

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