Dopamine D1 and D2 receptor antagonism during development alters later behavior in zebrafish

Behavioural Brain Research
A N Oliveri, Edward D Levin

Abstract

This study sought to examine the long-term behavioral impacts of dopamine D1 and D2 receptor antagonism during development in zebrafish (Danio rerio). Zebrafish embryos of both the AB* and 5D strains were exposed via immersion to either the D1 receptor antagonist SCH-23,390 or the D2 receptor antagonist haloperidol, at either 0.5 or 1.5-μM, from 5 h post-fertilization to 5 days post-fertilization. Aquarium water served as a control. Fish were then either tested as larvae on day 6 post-fertilization on a light/dark locomotor assay, or were grown to adulthood and tested on a behavioral battery that included assays for novel environment exploration, startle habituation, social affiliation, and predator escape (AB* strain only). Overall, developmental exposure to dopamine D1 and D2 receptor antagonists caused clear effects in larval locomotor behavior, driving hyperactivity in dark phases and hypoactivity in light phases. Additionally, control fish from the two strains were significantly different from each other (p < 0.05) with the AB* fish being more active than SD during the dark periods of the test. In the adult behavioral battery, developmental exposure to 1.5-μM of the D1 antagonist SCH-23390 significantly reduced activity (p...Continue Reading

Citations

Jul 4, 2020·The European Journal of Neuroscience·Murilo S de AbreuAllan V Kalueff
Aug 23, 2020·International Journal of Molecular Sciences·Ola Wasel, Jennifer L Freeman
Jan 29, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ana Carolina Monteiro de Souza LimaBruno Rezende Souza
Jan 26, 2021·The Journal of Comparative Neurology·Collette GoodeAlexandra Tallafuss
Jul 21, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Luís FélixCarlos Venâncio

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here