Dopamine-D1 and delta-opioid receptors co-exist in rat striatal neurons

Neuroscience Letters
L M AmbroseE J Van Bockstaele

Abstract

Cocaine's enhancement of dopaminergic neurotransmission in the mesolimbic pathway plays a critical role in the initial reinforcing properties of this drug. However, other neurotransmitter systems are also integral to the addiction process. A large body of data indicates that opioids and dopamine together mediate emotional and reinforced behaviors. In support of this, cocaine-mediated increases in activation of dopamine D1 receptors (D1R) results in a desensitization of delta-opioid receptor (DOR) signaling through adenylyl cyclase (AC) in striatal neurons. To further define cellular mechanisms underlying this effect, the subcellular distribution of DOR and D1R was examined in the rat dorsolateral striatum. Dual immunoperoxidase/gold-silver detection combined with electron microscopy was used to identify DOR and D1R immunoreactivities in the same section of tissue. Semi-quantitative analysis revealed that a subset of dendritic cellular profiles exhibited both DOR and D1R immunoreactivities. Of 198 randomly sampled D1R immunoreactive profiles, 43% contained DOR. Similarly of 165 DOR-labeled cellular profiles, 52% contained D1R. The present data provide ultrastructural evidence for co-existence between DOR and D1R in striatal neur...Continue Reading

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Citations

Apr 12, 2014·Frontiers in Neuroanatomy·Ralph J A Oude OphuisRoger A H Adan
Mar 20, 2014·British Journal of Pharmacology·Paul KlenowskiSelena E Bartlett
Jun 12, 2014·British Journal of Pharmacology·Wakako FujitaLakshmi A Devi
Oct 27, 2009·Progress in Neurobiology·Xu ZhangGuo-Qiang Ma

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