Dopamine D1 receptor activation contributes to light-adapted changes in retinal inhibition to rod bipolar cells

Journal of Neurophysiology
Michael D FloodErika D Eggers

Abstract

Dopamine modulation of retinal signaling has been shown to be an important part of retinal adaptation to increased background light levels, but the role of dopamine modulation of retinal inhibition is not clear. We previously showed that light adaptation causes a large reduction in inhibition to rod bipolar cells, potentially to match the decrease in excitation after rod saturation. In this study, we determined how dopamine D1 receptors in the inner retina contribute to this modulation. We found that D1 receptor activation significantly decreased the magnitude of inhibitory light responses from rod bipolar cells, whereas D1 receptor blockade during light adaptation partially prevented this decline. To determine what mechanisms were involved in the modulation of inhibitory light responses, we measured the effect of D1 receptor activation on spontaneous currents and currents evoked from electrically stimulating amacrine cell inputs to rod bipolar cells. D1 receptor activation decreased the frequency of spontaneous inhibition with no change in event amplitudes, suggesting a presynaptic change in amacrine cell activity in agreement with previous reports that rod bipolar cells lack D1 receptors. Additionally, we found that D1 recept...Continue Reading

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Citations

Feb 7, 2019·Journal of Neurophysiology·Reece E MazadeErika D Eggers
Feb 14, 2020·Investigative Ophthalmology & Visual Science·Nathalia Torres JimenezLinda K McLoon
Oct 29, 2020·Frontiers in Cellular Neuroscience·Kirill S KorshunovPaul Q Trombley
Sep 17, 2021·Frontiers in Neuroscience·Po-Chih ChenLi-Nien Chien
Nov 25, 2021·Journal of Neurophysiology·Michael D Flood, Erika D Eggers

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