Dopamine D1 receptor antagonist SCH 23390 retards methamphetamine sensitization in both combined administration and early posttreatment schedules in mice

Pharmacology, Biochemistry, and Behavior
H Kuribara

Abstract

SCH 23390 [0.003-0.03 mg/kg, subcutaneously (SC)], a dopamine D1 receptor antagonist, dose-dependently inhibited the ambulation-stimulant effect of methamphetamine (MAP) (2 mg/kg, SC) in mice when two drugs were combined in repeated administrations at 3- to 4-day intervals, repeated five times. SCH 23390 (0.03 mg/kg), which was sufficient to abolish the acute effect of MAP completely throughout the repeated administrations, significantly inhibited the induction of MAP sensitization. Moreover, when the mice were posttreated with SCH 23390 (0.01 and 0.03 mg/kg) 3 h after each MAP administration, at which the ambulation-stimulant effect of MAP had almost disappeared, they showed a significant and dose-dependent retardation of the induction of MAP sensitization. However, the 24-h posttreatment with SCH 23390 had no such effect. The administration of SCH 23390 (0.003-0.03 mg/kg) alone in either the activity cage or the home cage, or saline in the activity cage with 3- or 24-h posttreatment with SCH 23390 (0.01 or 0.03 mg/kg) five times at 3- to 4-day intervals did not elicit any significant changes in MAP sensitivity. The present results indicate that an intense blockade of dopamine D1 receptors in the acute or subacute period after...Continue Reading

References

May 18, 1984·European Journal of Pharmacology·R B MailmanD L Dehaven
Feb 1, 1984·Pharmacology, Biochemistry, and Behavior·H Kuribara, S Tadokoro
Dec 1, 1982·Pharmacology, Biochemistry, and Behavior·H Kuribara, S Tadokoro
Dec 1, 1981·Pharmacology, Biochemistry, and Behavior·M Hirabayashi, M R Alam
Jan 1, 1994·Pharmacology, Biochemistry, and Behavior·H Kuribara, Y Uchihashi
Sep 1, 1993·The Japanese Journal of Psychiatry and Neurology·H Kuribara, Y Uchihashi

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Citations

Jun 21, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wengang WangNigel S Bamford
Apr 21, 2016·Brain Research Bulletin·Rosana Camarini, Ricardo Marcos Pautassi
Aug 3, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Darakhshan Jabeen Haleem
Jul 13, 2019·Journal of Neuroscience Research·Nigel S Bamford, Wengang Wang
Mar 2, 2019·Current Neuropharmacology·Naveen SharmaHyoung-Chun Kim
Aug 25, 2018·Oxidative Medicine and Cellular Longevity·Fiona LimanaqiFrancesco Fornai
Mar 28, 2019·Frontiers in Pharmacology·Raphael Wuo-SilvaBeatriz M Longo
Nov 21, 2000·Annals of the New York Academy of Sciences·J ZhangM Xu
Mar 1, 2017·Archives of Pharmacal Research·Eun-Joo ShinHyoung-Chun Kim

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