Dopamine D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice

Investigative Ophthalmology & Visual Science
Furong HuangXiang-tian Zhou

Abstract

To determine the roles of dopamine D2 receptors (D2Rs) and dopamine D1 receptors (D1Rs) in the inhibition of form-deprivation myopia (FDM) by the nonselective dopamine agonist apomorphine (APO) in D2R-knockout (D2R-KO) and D1R-KO mice. Retinal layer thicknesses and electroretinograms (ERGs) were analyzed in KO mice and in D2R and D1R antagonist-treated mice. D2R-KO or D1R-KO mice and wild-type (WT) littermates were subjected to form deprivation during postnatal weeks 5 to 8. Both groups were intraperitoneally injected daily with either APO (5 μg/g body weight) dissolved in 1 μg/μL ascorbic acid or vehicle alone. Refraction, vitreous chamber depth (VCD), and axial length (AL), among other parameters, were measured prior to and at the end of the treatment period. The retinal layer thicknesses and ERGs in KO mice were similar to those treated with D2R and D1R antagonists. APO administration in WT mice inhibited the development of FDM by approximately 80%. FDM in D2R-KO mice was inhibited approximately 50% compared with WT mice and was further inhibited by APO to a level similar to that in APO-treated WT mice. FDM development in D1R-KO mice was similar to that in WT mice and was not affected by APO administration. The changes in VC...Continue Reading

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Citations

Jul 27, 2018·Eye & Contact Lens·Xiaoyan JiangKazuo Tsubota
Dec 7, 2018·Investigative Ophthalmology & Visual Science·Miaozhen PanXiangtian Zhou
Jun 18, 2020·Frontiers in Cellular Neuroscience·Seema BanerjeeFeng Pan
Sep 12, 2020·Scientific Reports·Jinglei YangXiangtian Zhou
Aug 22, 2020·Translational Vision Science & Technology·Fletcher J NgSeyhan Yazar
Nov 20, 2020·Investigative Ophthalmology & Visual Science·Xuan ZhouXiangtian Zhou
Dec 16, 2020·Journal of Medical Genetics·Fuxin ZhaoXiangtian Zhou
Jan 28, 2021·Investigative Ophthalmology & Visual Science·Erica G LandisMachelle T Pardue
Aug 26, 2021·Drug Design, Development and Therapy·Jiaxin BianMing Qi
Oct 6, 2021·Translational Vision Science & Technology·Quanqing GaoIra H Schachar
Jan 21, 2022·Investigative Ophthalmology & Visual Science·Furong HuangXiangtian Zhou

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