Dopamine D1 receptors, regulation of gene expression in the brain, and neurodegeneration.

CNS & Neurological Disorders Drug Targets
J L CadetNing Sheng Cai

Abstract

Dopamine (DA), the most abundant catecholamine in the basal ganglia, participates in the regulation of motor functions and of cognitive processes such as learning and memory. Abnormalities in dopaminergic systems are thought to be the bases for some neuropsychiatric disorders including addiction, Parkinson's disease, and Schizophrenia. DA exerts its arrays of functions via stimulation of D1-like (D1 and D5) and D2-like (D2, D3, and D4) DA receptors which are located in various regions of the brain. The DA D1 and D2 receptors are very abundant in the basal ganglia where they exert their functions within separate neuronal cell types. The present paper focuses on a review of the effects of stimulation of DA D1 receptors on diverse signal transduction pathways and gene expression patterns in the brain. We also discuss the possible involvement of the DA D1 receptors in DA-mediated toxic effects observed both in vitro and in vivo. Future studies using more selective agonist and antagonist agents and the use of genetically modified animals should help to further clarify the role of these receptors in the normal physiology and in pathological events that involve DA.

Citations

Oct 15, 2013·Veterinary Research Communications·Morteza ZendehdelShahin Hassanpour
Dec 22, 2015·Veterinary Research Communications·Mansour MahzouniSaeed Charkhkar
May 14, 2011·Expert Opinion on Emerging Drugs·Falko Biedermann, W Wolfgang Fleischhacker
Feb 14, 2016·Psychopharmacology·Irina N KrasnovaJean Lud Cadet
Dec 29, 2015·Pharmacology, Biochemistry, and Behavior·Christina N NonaJosé N Nobrega
Jul 16, 2011·Pharmacology, Biochemistry, and Behavior·Paromita Roy ChoudhuryUsha Rajamma
Dec 3, 2014·Brain Research·Edythe D LondonMichael E Ballard
May 15, 2012·Developmental Neurobiology·Déborah HeydetMichel R Leroux
Dec 18, 2012·Periodontology 2000·Binnaz LeblebiciogluAngelo Mariotti
Oct 2, 2015·Aging and Disease·Claudia Rangel-BarajasBenjamín Florán
Aug 27, 2015·Behavioral and Brain Functions : BBF·Karina VillalbaJean Lud Cadet
Feb 19, 2015·Amino Acids·Hans-Gert BernsteinWerner Hoffmann
Nov 19, 2013·Biological Psychiatry·Subramaniam JayanthiJean Lud Cadet
Feb 27, 2013·PloS One·Elena E UstinovaMichael R Shurin
Jul 29, 2016·Human Molecular Genetics·Michal GevaMichael R Hayden
Feb 23, 2017·Neurological Research·Siegfried MuhlackThomas Müller
Jun 13, 2018·Current Opinion in Nephrology and Hypertension·Oleg PalyginAlexander Staruschenko
May 31, 2019·International Journal of Paediatric Dentistry·Gizele Batista FrancoJoão Armando Brancher
Jun 5, 2016·The EMBO Journal·Kishore K JoshiChristopher Rongo
Jul 22, 2016·The EMBO Journal·Yee Lian Chew, William R Schafer
Feb 22, 2017·Pharmaceutical Biology·Patrick Brice Deeh DefoPierre Watcho
Aug 25, 2018·Oxidative Medicine and Cellular Longevity·Fiona LimanaqiFrancesco Fornai
Oct 11, 2017·Alzheimer's & Dementia : Translational Research & Clinical Interventions·S BarralY Stern
Dec 18, 2019·Biochimica Et Biophysica Acta. Biomembranes·Juan Francisco Bada JuarezAnthony Watts

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal ganglia in Parkinson's disease (MDS)

The basal ganglia is comprised of the neostriatum, the external and internal pallidal segments, the subthalamic nucleus, the substantia nigra pars reticulata, and the pars compacta of the substantia nigra. The basal ganglia circuitry is responsible for the correct execution of voluntary movements and is implicated in Parkinson's disease. Here is the latest research investigating the basal ganglia in Parkinson's disease.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.