Dopamine D2-receptor blockade enhances decoding of prefrontal signals in humans.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Thorsten KahntPhilippe N Tobler

Abstract

The prefrontal cortex houses representations critical for ongoing and future behavior expressed in the form of patterns of neural activity. Dopamine has long been suggested to play a key role in the integrity of such representations, with D2-receptor activation rendering them flexible but weak. However, it is currently unknown whether and how D2-receptor activation affects prefrontal representations in humans. In the current study, we use dopamine receptor-specific pharmacology and multivoxel pattern-based functional magnetic resonance imaging to test the hypothesis that blocking D2-receptor activation enhances prefrontal representations. Human subjects performed a simple reward prediction task after double-blind and placebo controlled administration of the D2-receptor antagonist amisulpride. Using a whole-brain searchlight decoding approach we show that D2-receptor blockade enhances decoding of reward signals in the medial orbitofrontal cortex. Examination of activity patterns suggests that amisulpride increases the separation of activity patterns related to reward versus no reward. Moreover, consistent with the cortical distribution of D2 receptors, post hoc analyses showed enhanced decoding of motor signals in motor cortex, ...Continue Reading

Citations

Feb 20, 2016·Neuron·Andrew Westbrook, Todd S Braver
Feb 3, 2016·ELife·Thorsten Kahnt, Philippe N Tobler
Jun 19, 2017·Neuroscience and Biobehavioral Reviews·Daniel MartinsDiana Prata
Jun 8, 2018·Journal of Cognitive Neuroscience·Apoorva BhandariDavid Badre
May 11, 2017·ELife·Tobias U HauserRaymond J Dolan
Jul 2, 2021·The International Journal of Neuropsychopharmacology·Tsen Vei LimKaren D Ersche
Jul 21, 2021·Journal of Neural Engineering·Hung-Yun LuSamantha R Santacruz
Nov 12, 2021·ELife·Alexander SoutschekPhilippe N Tobler

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