Dopamine D2 receptor gene (DRD2) haplotypes in Caucasians

Gene
U FinckhA Rolfs

Abstract

The human dopamine D2 receptor gene (DRD2) is considered a candidate gene for neuro-psychiatric diseases. We typed three new DNA sequence variants in DRD2 intron 4, intron 6 and exon 8, in combination with the known TaqI A restriction fragment length polymorphism (RFLP) and exon 7 311Ser/Cys in 106 unrelated psychiatrically healthy Caucasians. Based on the genotypic data we delineated 10 distinct DRD2 haplotypes and their genetic relationship. Our data provide evidence that the Taq A1 allele and the 311Cys variant are components of different groups of haplotypes though both variants have been speculated to be associated with alcoholism or schizophrenia in recent studies. Therefore we conclude that the prior knowledge of the frequencies and genetic relationships of DRD2 haplotypes will lead to the selection of more suitable intragenic markers for future association studies.

References

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Citations

Jan 3, 2001·European Journal of Pharmacology·A H WongH H Van Tol
Jul 6, 2000·European Psychiatry : the Journal of the Association of European Psychiatrists·P GorwoodJ Adès
Feb 29, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emma ChildsHarriet de Wit
May 15, 1998·Alcoholism, Clinical and Experimental Research·H J EdenbergH Begleiter
Jun 8, 2001·Alcoholism, Clinical and Experimental Research·I MatsumotoL G Schmidt
Jul 1, 1998·Environmental Health Perspectives·M A Rossing
Apr 13, 2004·Pharmacogenetics·Elaine C JohnstoneRobert T Walton
Dec 24, 2002·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ernest P Noble
Aug 1, 2015·European Journal of Anaesthesiology·Ulrich H FreyJürgen Peters
May 1, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Justyna Pełka-WysieckaJerzy Samochowiec

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