Dopamine D2 receptor mediates both inhibitory and stimulatory actions on prolactin release

Endocrine
A ChangS C Pang

Abstract

Dopamine is considered to be the major physiological tonic inhibitor of prolactin release, yet there is increasing evidence showing that it can also stimulate prolactin release from lactotrophs. In primary cultured lactotrophs, the major dopamine receptors responsible for inhibiting prolactin release are dopamine D2 receptors. A dopamine receptor subtype may be responsible for the stimulatory action, yet one cannot exclude the possibility that a dopamine D2 receptor can play dual roles. This study was therefore undertaken to investigate if dopamine both stimulates and inhibits prolactin secretion through activation of the same dopamine D2 receptor. GH4ZR7 cells, which have only one type of dopamine receptors--D2s, were perifused with different concentrations of dopamine, and the perifusate was assayed for prolactin; 10(-7) mol/L dopamine stimulated prolactin release (p < 0.05; n = 5), whereas 5 x 10(-4) mol/L dopamine inhibited prolactin secretion (p < 0.05; n = 5). In the pertussis toxin-treated cells, 10(-7) mol/L dopamine stimulated prolactin release (p < 0.05; n = 5), and 5 x 10(-4) mol/L dopamine did not significantly change the rate of prolactin release. These results indicate that both the stimulatory and inhibitory acti...Continue Reading

References

Apr 1, 1990·Physiological Reviews·S W Lamberts, R M Macleod
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Citations

Oct 24, 2006·Journal of Computational Neuroscience·Joël TabakRichard Bertram
Jul 24, 2010·Endocrine Reviews·Stanko S StojilkovicRichard Bertram
Feb 25, 2014·Frontiers in Neuroendocrinology·David J Lyons, Christian Broberger
Nov 2, 2021·Reproductive Sciences·Alessandra DiMauroStephen R Hammes

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