Dopamine D3 Receptors Modulate the Ability of Win-Paired Cues to Increase Risky Choice in a Rat Gambling Task

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Michael M Barrus, Catharine A Winstanley

Abstract

Similar to other addiction disorders, the cues inherent in many gambling procedures are thought to play an important role in mediating their addictive nature. Animal models of gambling-related behavior, while capturing dimensions of economic decision making, have yet to address the impact that these salient cues may have in promoting maladaptive choice. Here, we determined whether adding win-associated audiovisual cues to a rat gambling task (rGT) would influence decision making. Thirty-two male Long-Evans rats were tested on either the cued or uncued rGT. In these tasks, animals chose between four options associated with different magnitudes and frequencies of reward and punishing time-out periods. As in the Iowa Gambling Task, favoring options associated with smaller per-trial rewards but smaller losses and avoiding the tempting "high-risk, high-reward" decks maximized profits. Although the reinforcement contingencies were identical in both task versions, rats' choice of the disadvantageous risky options was significantly greater on the cued task. Furthermore, a D3 receptor agonist increased choice of the disadvantageous options, whereas a D3 antagonist had the opposite effects, only on the cued task. These findings are consi...Continue Reading

Citations

Dec 29, 2016·European Archives of Psychiatry and Clinical Neuroscience·Shin-Chang KuoSan-Yuan Huang
Jul 26, 2018·The European Journal of Neuroscience·Maria M DiehlDavid V Smith
Oct 31, 2018·Behavioural Pharmacology·Jacqueline-Marie N FerlandCatharine A Winstanley
Nov 6, 2018·Behavioural Pharmacology·Shelby L BlaesBarry Setlow
May 10, 2017·Annals of the New York Academy of Sciences·Katherine M NautiyalCarlos Blanco
Aug 22, 2017·Psychopharmacology·Patricia Di CianoBernard Le Foll
Jul 1, 2019·Psychopharmacology·Angela J LangdonCatharine A Winstanley
Dec 19, 2019·Frontiers in Behavioral Neuroscience·Brittany N KuhnAna-Clara Bobadilla
Jul 28, 2017·Scientific Reports·Aaron P SmithThomas R Zentall
Sep 15, 2018·Molecular Psychiatry·Luke ClarkMartin Zack
Nov 22, 2016·Journal of Neuroscience Research·Caitlin A Orsini, Barry Setlow
Feb 10, 2021·Addiction Biology·Tristan J HynesCatharine A Winstanley
Apr 10, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·T Celeste NapierAmanda L Persons
Mar 3, 2021·Psychopharmacology·Chloe S ChernoffCatharine A Winstanley
Aug 31, 2020·Current Opinion in Behavioral Sciences·Cole Vonder Haar
Jul 1, 2021·Psychopharmacology·Megan SwintoskySara E Morrison
Feb 5, 2017·Bio-protocol·Michael M Barrus, Catharine A Winstanley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Fiona D Zeeb, Catharine A Winstanley
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Fiona D ZeebCatharine A Winstanley
© 2022 Meta ULC. All rights reserved