PMID: 3407241Mar 1, 1988Paper

Dopamine delays gastric emptying and induces retrograde power contractions with enterogastric reflux

Zeitschrift für Gastroenterologie
H J Ehrlein


The purpose of the study was to elucidate the effects of dopamine on gastroduodenal motility and gastric emptying of an acaloric viscous meal. In four conscious dogs, antral, pyloric and duodenal contractions were recorded with extraluminal strain gage force transducers and induction coils. Gastric emptying was assessed radiographically. Dopamine at low dose (5 micrograms/kg x min) significantly diminished gastric emptying. It was mainly caused by a reduction in the contraction force of the antral waves. Dopamine at higher dose (10-15 micrograms/kg x min) induced retrograde power contractions accompanied by enterogastric reflux. When the dopamine infusion was stopped after the occurrence of a reverse power contraction, the antrum exhibited forceful contractions but gastric emptying ceased due to a profound decrease in antral tone. The results suggest that dopamine 1) inhibits gastric emptying of viscous meals, 2) induces reverse power contractions independently from vomiting, and that 3) antral tone is a basic requirement for gastric emptying of viscous meals.

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.