Dopamine desynchronizes the pace-making neuronal activity of rat respiratory rhythm generation

The European Journal of Neuroscience
Morimitsu FujiiA Arata

Abstract

In an excised Wistar rat medulla-spinal cord block preparation we previously found that dopamine slows respiratory rhythm by activation of dopamine D(4) receptors [Fujii et al., (2004)Neurosci. Res., 50, 355-359.] In the present paper, we investigated the effect of dopamine on pre-inspiratory (Pre-I) and inspiratory (I) neurons using the combination of an optical recording technique with a voltage-sensitive dye, unit recording and patch-clamp recording. Optical imaging of the ventral surface of the block preparation disclosed different locations and activity patterns of Pre-I and I neurons. In addition to slowing the rhythm, dopamine depressed respiratory activity of Pre-I neurons collectively but not that of I neurons. The dopaminergic suppression of Pre-I neurons was mimicked by a dopamine D(4) receptor agonist, PD168077. Unit recording and patch-clamp recording demonstrated that dopamine depolarizes Pre-I neurons, disperses Pre-I firing and depresses Pre-I phase postsynaptic potentials (PSPs) of I neurons. Immunohistological investigation revealed that Pre-I neurons express dopamine D(4) receptors. We found that approximately 60% of Pre-I neurons express dopamine D(4) receptors. These results show that dopaminergic respirato...Continue Reading

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Oct 19, 2004·Neuroscience Research·Morimitsu FujiiAkiko Arata

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Citations

Nov 5, 2011·The Journal of Physiological Sciences : JPS·Hiroshi Onimaru, Mathias Dutschmann
Jan 22, 2011·Clinical and Experimental Pharmacology & Physiology·Masanori KashiwagiJunzo Takeda
Mar 13, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peter M Lalley
Jun 14, 2008·Respiratory Physiology & Neurobiology·Luciane H GargaglioniLuiz Guilherme S Branco

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