Dopamine detection with fast-scan cyclic voltammetry used with analog background subtraction

Analytical Chemistry
Andre HermansR Mark Wightman

Abstract

Fast-scan cyclic voltammetry has been used in a variety of applications and has been shown to be especially useful to monitor chemical fluctuations of neurotransmitters such as dopamine within the mammalian brain. A major limitation of this procedure, however, is the large amplitude of the background current relative to the currents for the solution species of interest. Furthermore, the background tends to drift, and this drift limits the use of digital background subtraction techniques to intervals less than 90 s before distortion of dopamine signals occurs. To minimize the impact of the background, a procedure termed analog background subtraction is reported here. The background is recorded, and its inverse is played back to the current transducer during data acquisition so that it cancels the background in subsequent scans. Background drift still occurs and is recorded, but its magnitude is small compared to the original background. This approach has two advantages. First it allows the use of higher gains in the current transducer, minimizing quantization noise. Second, because the background amplitude is greatly reduced, principal component regression could be used to separate the contributions from drift, dopamine, and pH ...Continue Reading

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Citations

Sep 21, 2012·Psychopharmacology·Benjamin A ZimmerDavid C S Roberts
Jun 10, 2010·Analytical Chemistry·Richard B KeithleyR Mark Wightman
May 19, 2010·Analytical Chemistry·Benjamin J PrivettMark H Schoenfisch
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