PMID: 8596710Feb 1, 1996Paper

Dopamine directly activates a ligand-gated channel in snail neurones

Pflügers Archiv : European journal of physiology
K A GreenG A Cottrell

Abstract

Synaptically released dopamine is known to evoke fast as well as slow synaptic potentials in neurones of gastropod molluscs. Here evidence is presented that the fast excitatory response to dopamine is mediated by the direct activation of a ligand-gated channel: unitary currents were observed in outside-out patches of neurones exposed to dopamine, and the response persisted in the presence of intracellular guanosine 5'-o-(2-thiobiphosphate), GDP[beta-S], a condition known to block G-protein-coupled responses to dopamine and other agents. In whole-cell recordings, the fast response desensitized very rapidly; it was less desensitized in outside-out patches, suggesting dependence of desensitization on an intracellular factor. The response to dopamine was blocked by D-tubocurarine and strychnine (both probably by channel blockade), by apomorphine, chlorpromazine and relatively high doses of (+/-)-sulpiride and spiperone. The channel conducts predominantly monovalent cations. Unexpectedly, the fast response to dopamine was also observed in an identified dopaminergic neurone when maintained in isolation in culture. The receptors on the dopaminergic neurone were unevenly distributed, being more abundant on the axon-hillock, axon and ne...Continue Reading

References

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Citations

May 7, 2005·Neuroscience and Behavioral Physiology·V V AndrianovL N Muranova
Mar 16, 2004·Neuroscience Letters·Michael R DueKlaudiusz R Weiss
Oct 1, 1996·British Journal of Pharmacology·K A GreenG A Cottrell
Nov 23, 2006·The Journal of Experimental Biology·Oliver R BraubachRoger P Croll

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