Dopamine: effects on prolactin and luteinizing hormone secretion in ovariectomized rhesus macaques after transection of the pituitary stalk

Neuroendocrinology
K PavasuthipaisitH G Spies

Abstract

Luteinizing hormone (LH) and prolactin (PRL) levels were compared in the serum of ovariectomized rhesus macaques (Macaca mulatta) with pituitary-intact (PI) and surgically transected pituitary stalks (SS). After stalk sectioning, LH levels declined and PRL levels rose dramatically. Chronic infusion of intermittent pulses of gonadotropin-releasing hormone (GnRH; 1 microgram/min for 6 of every 60 min) into SS females reinitiated LH secretion within a few days despite increased PRL secretion. Continuous infusion of dopamine (10 micrograms/min/kg of body weight) for 9 days suppressed PRL levels in GnRH-infused SS females to near normal without alteration in basal serum LH levels or pulsatile LH release. A comparable dopamine regimen also failed to modify serum LH patterns in PI monkeys. Immediately after cessation of dopamine, serum PRL levels rose sharply in both PI and SS animals. Injection of estradiol benzoate (42 micrograms/kg of body weight) into SS monkeys receiving GnRH infusions resulted initially in LH suppression and then in LH release. However, the magnitude of LH release was less and the latency to its onset was longer in SS animals given estrogen than in PI controls with similar serum estrogen concentrations. It is un...Continue Reading

Citations

Jul 1, 1997·Pharmacology, Biochemistry, and Behavior·N K Mello, J H Mendelson
Nov 5, 1997·Pharmacology, Biochemistry, and Behavior·N K MelloJ W Sholar
Feb 1, 1987·Baillière's Clinical Endocrinology and Metabolism·I J Clarke, J T Cummins
Jun 1, 1983·Journal of Endocrinological Investigation·S M McCann

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