PMID: 9160246May 1, 1997Paper

Dopamine enhances somatostatin receptor-mediated inhibition of adenylate cyclase in rat striatum and hippocampus

Journal of Neuroscience Research
M N Rodriguez-SanchezE Arilla

Abstract

Although there is evidence that suggests that dopamine (DA) has stimulatory effects on somatostatinergic transmission, it is unknown to date if DA increases the activity of the somatostatin (SS) receptor-effector system in the rat brain. In this study, we evaluated the effects of the administration of DA and the DA D1-like (D1, D5) receptor antagonist SCH 23390 and the D2-like (D2, D3, D4) receptor antagonist spiperone on the SS receptor-adenylate cyclase (AC) system in the Sprague-Dawley rat striatum and hippocampus. An intracerebroventricular injection of DA (0.5 microgram/rat) increased the number of SS receptors and decreased their apparent affinity in the striatum and hippocampus 15 hr after its administration. The simultaneous administration of the DA receptor antagonists SCH 23390 (0.25 mg/kg, ip) and spiperone (0.1 mg/kg, ip) before DA injection partially prevented the DA-induced increase in SS binding. The administration of SCH 23390 plus spiperone alone produced a significant decrease in the number of SS receptors in both brain areas studied at 15 hr after injection, an effect that disappeared at 24 hr. The increased number of SS receptors in the DA-treated rats was associated with an increased capacity of SS to inhib...Continue Reading

References

Jan 1, 1992·Journal of Neural Transmission. General Section·A GarlindR F Cowburn
Sep 1, 1992·Neuropeptides·B ColásJ P Prieto
Dec 1, 1990·Journal of the Neurological Sciences·M AsanumaA Mori
May 15, 1990·Biochemical Pharmacology·T Reisine
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H L WangM Dichter
Feb 1, 1985·Neuroscience Research·R E CatalánJ E Godoy
Jan 1, 1985·Advances in Experimental Medicine and Biology·R Robbins
Jun 1, 1986·Pharmacology, Biochemistry, and Behavior·M T Martin-IversonS R Vincent
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S M MumbyA G Gilman
Sep 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·A G Gilman
Jan 1, 1969·Psychopharmacologia·J ConstantinidisF Geissbuhler
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C B Srikant, Y C Patel
Jun 15, 1984·Neuroscience Letters·M F Beal, J B Martin
Aug 31, 1984·Neuroscience Letters·J C Reubi
Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard
Mar 1, 1995·Trends in Pharmacological Sciences·D HoyerJ E Taylor
Oct 1, 1993·Journal of Endocrinological Investigation·M T de los FrailesF Sánchez Franco
Aug 1, 1993·Brain Research. Molecular Brain Research·R E SeeP W Kalivas

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Citations

Jan 15, 2010·Journal of Neurochemistry·Matthew James GirgentiSamuel Sathyanesan Newton
Aug 12, 2004·Neuroreport·David Aguado-LleraVicente Barrios
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Song-Guang RenShlomo Melmed
Feb 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R S WeisingerB Purcell
May 2, 2018·Psychopharmacology·Agata Faron-GóreckaMarta Dziedzicka-Wasylewska
May 10, 2003·Neurobiology of Learning and Memory·Jefferson W KinneyJacqueline N Crawley

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