PMID: 8370570Jan 1, 1993Paper

Dopamine formation, from its immediate precursor 3,4-dihydroxyphenylalanine, along the rat digestive tract

Fundamental & Clinical Pharmacology
M A Vieira-Coelho, P Soares-da-Silva


The formation of dopamine, from L-3,4-dihydroxyphenylalanine (L-dopa), in fragments of non-glandular and glandular stomach, duodenum, jejunum, ileum and proximal and distal colon of the rat was examined. The deamination of newly-formed dopamine into 3,4-dihydroxyphenylacetic acid (dopac) was also studied. The synthesis of dopamine in tissues incubated with 500 microM L-dopa for 20 min in conditions of catechol-O-methyltransferase (Comt) inhibition was found to be in the duodenum, jejunum and ileum 2-fold that in the proximal colon, 6-fold that in the glandular stomach and 120-fold that in the non-glandular stomach and distal colon. The formation of dopac in these tissues followed the pattern of amine formation. In the jejunum, the formation of dopamine and dopac was found to be dependent on the concentration of L-dopa (50 to 5000 microM) used. In another set of experiments, it was found that the formation of dopamine in jejunal segments loaded with increasing concentrations of L-dopa (50, 100 and 500 microM) was a time-dependent process. The rate constant (k) of formation of dopamine as a function of time was found to be similar (0.050 +/- 0.005) with either concentration of L-dopa; the rate constant of dopac formation in these...Continue Reading


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Jan 1, 1990·Journal of Autonomic Pharmacology·P Soares-da-Silva, M H Fernandes
Jun 1, 1987·The Journal of Pharmacy and Pharmacology·K IwamotoT Matsushita
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Dec 1, 1985·Scandinavian Journal of Gastroenterology·H GraffnerE Rosengren
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