PMID: 8370570Jan 1, 1993Paper

Dopamine formation, from its immediate precursor 3,4-dihydroxyphenylalanine, along the rat digestive tract

Fundamental & Clinical Pharmacology
M A Vieira-Coelho, P Soares-da-Silva

Abstract

The formation of dopamine, from L-3,4-dihydroxyphenylalanine (L-dopa), in fragments of non-glandular and glandular stomach, duodenum, jejunum, ileum and proximal and distal colon of the rat was examined. The deamination of newly-formed dopamine into 3,4-dihydroxyphenylacetic acid (dopac) was also studied. The synthesis of dopamine in tissues incubated with 500 microM L-dopa for 20 min in conditions of catechol-O-methyltransferase (Comt) inhibition was found to be in the duodenum, jejunum and ileum 2-fold that in the proximal colon, 6-fold that in the glandular stomach and 120-fold that in the non-glandular stomach and distal colon. The formation of dopac in these tissues followed the pattern of amine formation. In the jejunum, the formation of dopamine and dopac was found to be dependent on the concentration of L-dopa (50 to 5000 microM) used. In another set of experiments, it was found that the formation of dopamine in jejunal segments loaded with increasing concentrations of L-dopa (50, 100 and 500 microM) was a time-dependent process. The rate constant (k) of formation of dopamine as a function of time was found to be similar (0.050 +/- 0.005) with either concentration of L-dopa; the rate constant of dopac formation in these...Continue Reading

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Citations

Oct 7, 1998·European Journal of Pharmacology·M A Vieira-Coelho, P Soares-da-Silva
Feb 26, 2000·Acta Physiologica Scandinavica·V Lucas-TeixeiraP Soares-Da-Silva
Feb 25, 2003·The Journal of Physiology·Rebecca S LamMarek Duszyk
Jan 1, 1997·Clinical and Experimental Hypertension : CHE·M A Vieira-CoelhoP Soares-da-Silva
Aug 11, 2000·Clinical and Experimental Hypertension : CHE·V A Lucas-TeixeiraP Soares-da-Silva
Nov 10, 2015·Experimental Physiology·Patrício Soares-da-SilvaFernando Magro
Apr 9, 2014·Frontiers in Immunology·Rodrigo PachecoMoncef Zouali
Oct 30, 2016·International Journal of Biological Macromolecules·Mohammad Rehan AjmalRizwan Hasan Khan
May 25, 2002·Acta Physiologica Scandinavica·S FragaP Soares-da-Silva
Sep 1, 1996·Neurochemical Research·M D BerryA A Boulton
Aug 10, 2005·American Journal of Nephrology·B Sampaio-MaiaM Pestana
Mar 3, 2006·Nephrology·Benedita Sampaio-MaiaManuel Pestana
Oct 20, 2005·American Journal of Respiratory Cell and Molecular Biology·Alejandro M Bertorello, Jacob I Sznajder
Mar 10, 2015·Molecular Endocrinology·Antonella MaffeiPaul E Harris
Jul 15, 1999·The Journal of Clinical Endocrinology and Metabolism·D S GoldsteinG Eisenhofer
Jan 9, 2018·Cranio : the Journal of Craniomandibular Practice·Päivi JussilaAune Raustia
Jun 27, 2018·Pharmacological Reviews·Raul R GainetdinovMark D Berry
Jan 11, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Moshe Yair KasirerJaques Belik
Aug 5, 1998·The American Journal of Physiology·M A Vieira-Coelho, P Soares-Da-Silva
Nov 30, 2000·American Journal of Physiology. Renal Physiology·M A Vieira-CoelhoP Soares-da-Silva
Jul 18, 2018·Frontiers in Pharmacology·Sherri L Christian, Mark D Berry
Sep 29, 2020·Journal of Biomedical Science·Lesha Pretorius, Carine Smith
Aug 12, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C J VaughanD P O'Connell
Aug 28, 2020·Animals : an Open Access Journal From MDPI·Giampaolo BosiBahram Sayyaf Dezfuli
Mar 29, 2000·The Journal of Nutrition·V Lucas-TeixeiraP Soares-Da-Silva

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