Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake

Brain and Behavior
Omar Ramos-LopezMENA Project

Abstract

Dopamine (DA) is a neurotransmitter that regulates the rewarding and motivational processes underlying food intake and eating behaviors. This study hypothesized associations of DNA methylation signatures at genes modulating DA signaling with obesity features, metabolic profiles, and dietary intake. An adult population within the Methyl Epigenome Network Association project was included (n = 473). DNA methylation levels in white blood cells were measured by microarray (450K). Differentially methylated genes were mapped within the dopaminergic synapse pathway using the KEGG reference database (map04728). Subsequently, network enrichment analyses were run in the pathDIP portal. Associations of methylation patterns with anthropometric markers of general (BMI) and abdominal obesity (waist circumference), the blood metabolic profile, and daily dietary intakes were screened. After applying a correction for multiple comparisons, 12 CpG sites were strongly associated (p < 0.0001) with BMI: cg03489495 (ITPR3), cg22851378 (PPP2R2D), cg04021127 (PPP2R2D), cg22441882 (SLC18A1), cg03045635 (DRD5), cg23341970 (ITPR2), cg13051970 (DDC), cg08943004 (SLC6A3), cg20557710 (CACNA1C), cg24085522 (GNAL), cg16846691 (ITPR2), and cg09691393 (SLC6A3). M...Continue Reading

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Citations

Jul 30, 2020·Medicina·Andrea Maugeri, Martina Barchitta
Jul 1, 2020·International Journal of Molecular Sciences·Ana Florencia Vega-BenedettiPatrizia Zavattari
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Jan 8, 2022·Biochemical Society Transactions·Priyadarshni PatelThangiah Geetha

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Methods Mentioned

BETA
chips

Software Mentioned

SPSS
GraphPad Prism
LIMMA
ComBat
R
GenomeStudio Methylation Software
Pathway Data Integration Portal ( pathDIP )
Ensembl

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