Dopamine in plasma of lateral and medial hypophysial portal vessels: evidence for regional variation in the release of hypothalamic dopamine into hypophysial portal blood

Endocrinology
M J ReymondJ C Porter

Abstract

The plasma concentrations of dopamine in blood from hypophysial portal vessels in various locations on the pituitary stalk were evaluated in diestrous rats. It was found that the mean concentration of dopamine in blood from lateral hypophysial portal vessels, which contain the venous effluent of the lateral median eminence, was significantly less (P less than 0.005) than that in blood from medial portal vessels, which contain the venous effluent of the medial median eminence [1.59 +/- (SE) 0.23 ng/ml vs. 3.12 +/- 0.48 ng/ml]. The mean plasma concentration of dopamine in blood of lateral portal vessels and of medial portal vessels was at least 20-40 times greater than that in arterial blood of these animals. It was calculated that the rate of release of hypothalamic dopamine was 174 +/- 38 pg/h into a medial portal vessel and 73 +/- 15 pg/h into a lateral portal vessel. The mean plasma concentration of norepinephrine or epinephrine in blood from a medial portal vessel was not different from that from a lateral portal vessel. To address the issue of whether the rate of release of dopamine into a medial portal vessel and into a lateral portal vessel was correlated with the rate of synthesis of dopamine in discrete regions of the m...Continue Reading

Citations

Jan 1, 1989·Progress in Neurobiology·N Ben-JonathanJ F Hyde
Sep 1, 1986·Molecular and Cellular Endocrinology·J Lafond, R Collu
Apr 1, 1991·Molecular and Cellular Endocrinology·P MukherjeeW C Hymer
Sep 27, 2003·General and Comparative Endocrinology·Jonathan D JohnstonAndrew S I Loudon
Nov 25, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·E L AnthonyA W Gustafson
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P S Wang, J C Porter
Jun 1, 1989·The Journal of Clinical Investigation·R ParadisiC Flamigni
Jul 18, 2001·Neuroscience·L J Freedman, C Shi
Oct 13, 2012·Auris, Nasus, Larynx·Chang-Hee KimJun Ho Lee
Feb 1, 1987·Baillière's Clinical Endocrinology and Metabolism·I J Clarke, J T Cummins
May 16, 1988·Biochemical and Biophysical Research Communications·J M GoldmanK C Booth
Jul 16, 2016·ACS Applied Materials & Interfaces·Luyun JiangJohn S Foord
Oct 1, 1989·Journal of Endocrinological Investigation·F CamanniE E Müller
Jun 1, 1991·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M TerzoloA Angeli

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