Dopamine infusion and anterior pituitary gland function in very low birth weight infants

Biology of the Neonate
Luca FilippiSalvatore Seminara

Abstract

Previous studies demonstrated that dopamine infusion reduces plasma concentration of thyroxine (T4), thyroid stimulating hormone (TSH), prolactin (PRL), and growth hormone (GH) in adults, children, and infants. The purpose of this prospective observational study was to evaluate the relationship between dopamine infusion and the dynamics of T4, TSH, PRL, and GH in preterm newborns weighing less than 1,500 g (very low birth weight infants, VLBW) admitted in a neonatal intensive care unit of a university hospital over a one year period. A total of 97 preterm newborns were enrolled and divided into two groups: group B included hypotensive infants treated with plasma expanders and dopamine infusion; group A was the control group including newborns who were never treated with dopamine. The newborns were studied dynamically through blood samples taken every day till 10 days. Newborns of group B were studied during dopamine infusion and after its withdrawal. Among the VLBW newborns who were given dopamine, the four pituitary hormones had different dynamics: a reduction of T4, TSH, and PRL levels was noticed since the first day of treatment, and a rebound of their levels was evident since the first day after its interruption. On the con...Continue Reading

References

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Citations

Mar 3, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·Luca FilippiCristina Santoro
Jul 12, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sadrettin EkmenUgur Dilmen
Nov 28, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Bryan R Haugen
Jul 13, 2007·Current Opinion in Obstetrics & Gynecology

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